异丙酚恒速输注对异氟烷麻醉犬疑似反射性支气管收缩的潜在支气管扩张作用的研究。

Investigation of the potential bronchodilatory effect of propofol constant rate infusion for suspected reflex bronchoconstriction in isoflurane-anesthetized dogs.

作者信息

Kim Minha, Lee Inhyung, Son Won-Gyun

出版信息

Am J Vet Res. 2025 Apr 16;86(7). doi: 10.2460/ajvr.24.11.0345. Print 2025 Jul 1.

DOI:10.2460/ajvr.24.11.0345

PMID:40239698

Abstract

OBJECTIVE

To evaluate the bronchodilatory effect of propofol constant rate infusion (CRI) on PaO2 and PaCO2 in dogs with suspected bronchoconstriction.

METHODS

In this retrospective, observational study, anesthetic records from August 2022 through July 2023 at the Seoul National University Veterinary Medical Teaching Hospital were reviewed. Dogs with PaO2 < 300 mm Hg and PaCO2 > 45 mm Hg during mechanical ventilation under inhalation anesthesia receiving a propofol CRI were included. Ventilatory parameters and arterial blood gas results were extracted, reported as median (range). Arterial partial pressure of oxygen and PaCO2 values before and after propofol CRI were compared.

RESULTS

7 client-owned dogs were identified. Bronchoconstriction was suspected postintubation based on ventilatory parameters (tidal volume of 8.1 [6.0 to 9.3] mL/kg; compliance respiratory system of 0.6 [0.4 to 0.8] mL/cm H2O/kg) and arterial blood gas results. Despite immediate interventions, including optimizing mechanical ventilation, deepening anesthesia, and drug therapy, PaO2 remained < 300 mm Hg. Thus, a propofol CRI (12 to 14 mg/kg/h) was initiated. Arterial partial pressure of oxygen increased following propofol CRI, rising from 153.0 (75.5 to 233.0) mm Hg to 284.0 (183.0 to 386.0) mm Hg at 30 minutes (mean difference, 130.9 mm Hg; 95% CI, 21.4 to 240.3) and to 331.5 (236.0 to 458.0) mm Hg at 60 minutes (mean difference, 168.0 mm Hg; 95% CI, 93.0 to 244.5). Arterial partial pressure of carbon dioxide levels were similar without improvement. Postoperatively, 4 dogs exhibited hypoxemia, taking 60 to 135 minutes to recover.

CONCLUSIONS

In dogs with perioperative gas exchange problems, PaO2 increased after propofol CRI, though PaCO2 levels remained unchanged.

CLINICAL RELEVANCE

Propofol CRI improved oxygenation in dogs with suspected bronchoconstriction and may serve as a bronchodilatory treatment option.

摘要

目的

评估丙泊酚持续输注（CRI）对疑似支气管收缩犬的动脉血氧分压（PaO2）和动脉血二氧化碳分压（PaCO2）的支气管扩张作用。

方法

在这项回顾性观察研究中，回顾了首尔国立大学兽医学院教学医院2022年8月至2023年7月的麻醉记录。纳入在吸入麻醉下机械通气期间接受丙泊酚CRI且PaO2<300 mmHg和PaCO2>45 mmHg的犬。提取通气参数和动脉血气结果，以中位数（范围）报告。比较丙泊酚CRI前后的动脉血氧分压和PaCO2值。

结果

确定了7只客户拥有的犬。根据通气参数（潮气量8.1[6.0至9.3]mL/kg；呼吸系统顺应性0.6[0.4至0.8]mL/cm H2O/kg）和动脉血气结果，怀疑插管后发生支气管收缩。尽管立即采取了干预措施，包括优化机械通气、加深麻醉和药物治疗，但PaO2仍<300 mmHg。因此，开始丙泊酚CRI（12至14 mg/kg/h）。丙泊酚CRI后动脉血氧分压升高，30分钟时从153.0（75.5至233.0）mmHg升至284.0（183.0至386.0）mmHg（平均差值130.9 mmHg；95%置信区间，21.4至240.3），60分钟时升至331.5（236.0至458.0）mmHg（平均差值168.0 mmHg；95%置信区间，93.0至244.5）。动脉血二氧化碳分压水平相似，无改善。术后，4只犬出现低氧血症，恢复时间为60至135分钟。