Nixon Nisha, Cheng Kelly H, Richards Allan, Martin Howard, Snead Martin P, Muthusamy Brinda
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Faculty of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
J AAPOS. 2025 Jun;29(3):104206. doi: 10.1016/j.jaapos.2025.104206. Epub 2025 Apr 14.
Studies of myopia progression in congenital myopia, as seen in genetically confirmed Stickler syndrome, are scarce. Stickler syndrome represents the most common cause of rhegmatogenous retinal detachment in children. The purpose of this retrospective study was to determine the rate of myopia progression in a cohort of 40 children (75 eyes) with type 1 Stickler syndrome (COL2A1 mutation) and 5 children (10 eyes) with type 2 Stickler syndrome (COL11A1 mutation). In this cohort, the median rate of progression was -0.08 D per year for those with type 1 Stickler syndrome and -0.12 D per year for those with type 2 Stickler syndrome, indicating minimal myopia progression in these children.
对于先天性近视（如经基因确诊的斯蒂克勒综合征所见）的近视进展研究很少。斯蒂克勒综合征是儿童孔源性视网膜脱离最常见的病因。这项回顾性研究的目的是确定一组40名患有1型斯蒂克勒综合征（COL2A1突变）的儿童（75只眼）和5名患有2型斯蒂克勒综合征（COL11A1突变）的儿童（10只眼）的近视进展率。在这个队列中，1型斯蒂克勒综合征患者的年进展中位数为-0.08 D，2型斯蒂克勒综合征患者为-0.12 D，表明这些儿童的近视进展极小。
