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阿苯达唑治疗自然感染绵羊的肺包虫囊肿：一项与人类包虫囊肿治疗相关的研究

Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man.

作者信息

Morris D L, Clarkson M J, Stallbaumer M F, Pritchard J, Jones R S, Chinnery J B

出版信息

Thorax. 1985 Jun;40(6):453-8. doi: 10.1136/thx.40.6.453.

DOI:10.1136/thx.40.6.453
PMID:4024006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC460104/
Abstract

Albendazole was given orally to sheep with naturally occurring live pulmonary and hepatic cysts. The viability of pulmonary cysts was established before treatment by thoracotomy and needle puncture. Both 10 and 20 mg/kg/day doses were found effective in that no viable protoscoleces were found after six weeks' treatment in either group while untreated controls still had viable cysts. In addition, treated animals showed macroscopic and electron microscopic changes. Bone marrow toxicity probably occurred in two sheep.

摘要

给自然感染有活的肺和肝囊肿的绵羊口服阿苯达唑。在治疗前通过开胸手术和针刺确定肺囊肿的活力。发现10毫克/千克/天和20毫克/千克/天的剂量均有效，因为在六周治疗后两组中均未发现存活的原头节，而未治疗的对照组仍有存活的囊肿。此外，治疗的动物显示出宏观和电子显微镜下的变化。可能有两只绵羊出现了骨髓毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/000db1ae75a9/thorax00234-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/42521f990ded/thorax00234-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/25992509d64e/thorax00234-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/1a89fb88c15c/thorax00234-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/000db1ae75a9/thorax00234-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/42521f990ded/thorax00234-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/25992509d64e/thorax00234-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/1a89fb88c15c/thorax00234-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8a/460104/000db1ae75a9/thorax00234-0057-a.jpg

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Is alveolar hydatid disease of the liver incurable?肝脏肺泡状棘球蚴病无法治愈吗？
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Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep.评价奥芬达唑、吡喹酮和阿苯达唑治疗囊型包虫病的效果：一项自然感染绵羊的随机临床试验。
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Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep.硝唑尼特和奥芬达唑对自然感染绵羊的囊型棘球蚴病疗效评估。
Am J Trop Med Hyg. 2009 Mar;80(3):367-72.
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Oxfendazole treatment of sheep with naturally acquired hydatid disease.用奥芬达唑治疗自然感染包虫病的绵羊。
Antimicrob Agents Chemother. 1999 Sep;43(9):2263-7. doi: 10.1128/AAC.43.9.2263.
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Antimicrob Agents Chemother. 1998 Mar;42(3):601-5. doi: 10.1128/AAC.42.3.601.
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Penetration of albendazole sulphoxide into hydatid cysts.阿苯达唑亚砜在包虫囊肿中的渗透情况。
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Serology in patients treated with albendazole for hydatid disease.接受阿苯达唑治疗包虫病患者的血清学研究。
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