Bryceson A D, Cowie A G, Macleod C, White S, Edwards D, Smyth J D, McManus D P
Trans R Soc Trop Med Hyg. 1982;76(4):510-8. doi: 10.1016/0035-9203(82)90151-1.
Eleven heterogeneous patients with inoperable hydatid disease were treated with high doses of oral mebendazole, up to 200 mg/kg/day for 16 to 48 weeks. Toxicity was not encountered. Despite careful assessment it proved difficult critically to evaluate the efficacy of mebendazole. In four patients chemotherapy appeared to have been at least partially successful and success seems to have correlated with serum levels in excess of 100 ng/ml one to three hours after dosage. The problems of assessment are discussed and the need for controlled trials of mebendazole in hydatid disease are stressed.
11例患有无法手术的包虫病的异质性患者接受了大剂量口服甲苯达唑治疗，剂量高达200mg/kg/天，持续16至48周。未出现毒性反应。尽管进行了仔细评估，但事实证明很难严格评估甲苯达唑的疗效。在4例患者中，化疗似乎至少部分取得了成功，而且成功似乎与给药后1至3小时血清水平超过100ng/ml相关。文中讨论了评估问题，并强调了在包虫病中进行甲苯达唑对照试验的必要性。
