Uchimura Yuki, Sim Juin Jia, Hirano Shinji, Hifumi Tatsuro, Miyoshi Noriaki, Takahashi Masashi, Endo Yasuyuki
Laboratory of Small Animal Internal Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Laboratory of Veterinary Pathology, Joint of Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
J Vet Med Sci. 2025 Jun 1;87(6):626-633. doi: 10.1292/jvms.24-0503. Epub 2025 Apr 17.
Felis catus papillomavirus (FcaPV) was first discovered in 2002. Seven genotypes (FcaPV-1/-2/-3/-4/-5/-6/-7) have been reported to date, at least one of which (FcaPV-2) is suggested to be implicated in squamous cell carcinoma (SCC); however, relevant epidemiological data on Japanese cats are limited. There is one report on relatively low FcaPV-2 prevalence in cats with SCC, largely in the Tokyo region. In this study, we investigated the prevalence of each FcaPV genotype in cats with SCC largely drawn from a peripheral region of Japan (Kyushu). Formalin-fixed paraffin-embedded (FFPE) specimens from 107 cats with SCC were subjected to DNA extraction for type-specific PCR assays, followed by confirmatory nucleotide sequencing. Overall, 16 cases (15.0%) were positive for FcaPV, and the results detected for FcaPV-1/-2/-3/-4/-5/-6/-7 were 0/107 (0.0%), 7/107 (6.5%), 4/107 (3.7%), 1/107 (0.9%), 3/107 (2.8%), 1/107 (0.9%), and 1/107 (0.9%), respectively. Our results suggest that FcaPV-2 is the prevalent papillomavirus type in cats with SCC across Japan, but the figure is lower than in other countries. This is also the first report on the detection of FcaPV-6 and FcaPV-7 in Japan, which previously have only been reported in Australia and New Zealand, respectively.
猫乳头瘤病毒（FcaPV）于2002年首次被发现。迄今为止，已报告了7种基因型（FcaPV - 1/-2/-3/-4/-5/-6/-7），其中至少有一种（FcaPV - 2）被认为与鳞状细胞癌（SCC）有关；然而，关于日本猫的相关流行病学数据有限。有一份报告指出，在鳞状细胞癌猫中，FcaPV - 2的患病率相对较低，主要集中在东京地区。在本研究中，我们调查了主要来自日本周边地区（九州）的鳞状细胞癌猫中每种FcaPV基因型的患病率。对107只鳞状细胞癌猫的福尔马林固定石蜡包埋（FFPE）标本进行DNA提取，用于型特异性PCR检测，随后进行验证性核苷酸测序。总体而言，16例（15.0%）FcaPV呈阳性，FcaPV - 1/-2/-3/-4/-5/-6/-7的检测结果分别为0/107（0.0%）、7/107（6.5%）、4/107（3.7%）、1/107（0.9%）、3/107（2.8%）、1/107（0.9%）和1/107（0.9%）。我们的结果表明，FcaPV - 2是日本鳞状细胞癌猫中普遍存在的乳头瘤病毒类型，但该数字低于其他国家。这也是日本首次关于检测到FcaPV - 6和FcaPV - 7的报告，此前它们分别仅在澳大利亚和新西兰被报道过。
