调查猫口腔鳞状细胞癌中多种猫乳头状瘤病毒类型（-1/-2/-3/-4/-5/-6）DNA：一项多中心研究。
Investigation of multiple Felis catus papillomavirus types (-1/-2/-3/-4/-5/-6) DNAs in feline oral squamous cell carcinoma: a multicentric study.
机构信息
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana 'M. Aleandri', Rome, Italy.
出版信息
J Vet Med Sci. 2022 Jun 18;84(6):881-884. doi: 10.1292/jvms.22-0060. Epub 2022 Apr 15.
Abstract
Recent evidence suggests a possible association of Felis catus papillomavirus type 2 (FcaPV-2) DNA with feline oral squamous cell carcinoma (FOSCC). In this study, type-specific PCR targeting two genes (L1/E6 or E1/E6) of FcaPV-1/-2/-3/-4/-5/-6 was performed to detect viral DNA in a large amount of FOSCC samples collected in Italy and Austria. FcaPV-1/-2/-3/-4/-5 were detected in 7/113 (6.2%), 7/93 (7.5%), 6/113 (5.3%), 1/113 (0.9%) and 2/113 (1.8%) specimens, respectively, with different prevalences in Italian vs. Austrian samples, whilst FcaPV-6 went undetected. Our results confirms that FcaPV-2 is the most prevalent in FOSCC, followed by FcaPV-1/-3 and suggest that FcaPVs have variable circulation rates in European countries.
摘要
最近的证据表明，猫科动物乳头瘤病毒 2 型（FcaPV-2）DNA 可能与猫口腔鳞状细胞癌（FOSCC）有关。在这项研究中，使用针对 FcaPV-1/-2/-3/-4/-5/-6 两种基因（L1/E6 或 E1/E6）的特定类型 PCR 检测了在意大利和奥地利收集的大量 FOSCC 样本中的病毒 DNA。在 113 个样本中分别检测到了 FcaPV-1/-2/-3/-4/-5，检出率分别为 6.2%、7.5%、5.3%、0.9%和 1.8%，在意大利和奥地利样本中存在差异，而 FcaPV-6 未被检出。我们的结果证实 FcaPV-2 在 FOSCC 中最为普遍，其次是 FcaPV-1/-3，并表明 FcaPV 在欧洲国家的传播率存在差异。
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