Song Jingyan, Huang Jie, Mao Jian, Cao Jing, Zhao Qinghua
Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, No.1,Youyi Road, Yuzhong District, Chongqing, 400016, China.
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Eur J Clin Pharmacol. 2025 Apr 17. doi: 10.1007/s00228-025-03831-9.
This study aimed to investigate the impact of a medication discrepancy management platform on reducing medication discrepancies among elderly patients with polypharmacy and to analyze influencing factors.
A total of 110 elderly polypharmacy patients were divided into a control group and an observation group using a random number method, each with 55 participants. The control group received routine management, while the observation group utilized a medication discrepancy management platform. Medication knowledge and adherence before and after intervention were compared between the two groups. Reasons and types of medication discrepancies were statistically analyzed. Patients were divided into a non-discrepancy group and a discrepancy group, with multivariate logistic regression used to analyze factors influencing medication discrepancies among elderly patients with polypharmacy.
Utilizing a medication discrepancy management platform significantly improved medication knowledge and adherence among elderly patients (P < 0.05). A total of 34 patients (30.91%) experienced at least one medication discrepancy within one-week post-discharge, primarily involving decreased frequency, missed doses, reduction in medication types, and medication substitution. Multivariate logistic regression analysis showed that the use of the medication discrepancy management platform, caregiver involvement, and prescribed discharge medications (7-8 types or ≥ 9 types) were independent factors influencing medication discrepancies in elderly patients (P < 0.05).
Using a medication discrepancy management platform can effectively reduce medication discrepancies in elderly patients with polypharmacy and improve elderly patients' adherence to medication. Expanding the platform's use can enhance discharge guidance quality and ensure medication safety.
本研究旨在探讨用药差异管理平台对减少老年多病患者用药差异的影响,并分析影响因素。
采用随机数字法将110例老年多病患者分为对照组和观察组,每组55例。对照组接受常规管理,观察组使用用药差异管理平台。比较两组干预前后的用药知识和依从性。对用药差异的原因和类型进行统计分析。将患者分为无差异组和差异组,采用多因素logistic回归分析老年多病患者用药差异的影响因素。
使用用药差异管理平台显著提高了老年患者的用药知识和依从性(P<0.05)。共有34例患者(30.91%)在出院后1周内至少出现1次用药差异,主要包括用药频次减少、漏服、用药种类减少和药物替换。多因素logistic回归分析显示,使用用药差异管理平台、照顾者参与以及出院带药种类(7~8种或≥9种)是影响老年患者用药差异的独立因素(P<0.05)。
使用用药差异管理平台可有效减少老年多病患者的用药差异,提高老年患者的用药依从性。扩大该平台的应用可提高出院指导质量,确保用药安全。