Hashimoto K, Shibuya T, Imai S
Tohoku J Exp Med. 1985 Apr;145(4):359-67. doi: 10.1620/tjem.145.359.
Cardiovascular effects of antiarrhythmic drugs and their effects on the respiratory rate were examined in conscious beagles. Disopyramide, 1.5 mg/kg i.v., increased the blood pressure and decreased the heart rate, but higher dose of 5 mg/kg i.v. increased both. Disopyramide showed no central nervous side effects. Procainamide, 20 and 60 mg/kg i.v., increased the blood pressure and heart rate without changing the respiratory rate. A higher dose (60 mg/kg i.v.) of procainamide induced vomiting. Lidocaine, 2 and 6 mg/kg i.v., and phenytoin, 3 and 10 mg/kg i.v., simultaneously increased the blood pressure, heart rate and respiratory rate accompanied by excitement, and with a higher dose (6 mg/kg i.v.) of lidocaine, by convulsions. Verapamil, 0.1 and 0.3 mg/kg i.v., induced tachycardia without serious neurological effects. In conscious healthy dogs cardiovascular depressant actions of antiarrhythmic drugs could only rarely be observed.
在清醒的比格犬身上研究了抗心律失常药物的心血管效应及其对呼吸频率的影响。静脉注射1.5毫克/千克的丙吡胺可使血压升高、心率降低，但静脉注射5毫克/千克的更高剂量则会使两者均升高。丙吡胺未显示出中枢神经副作用。静脉注射20毫克/千克和60毫克/千克的普鲁卡因酰胺可使血压和心率升高，而呼吸频率不变。更高剂量（静脉注射60毫克/千克）的普鲁卡因酰胺会引起呕吐。静脉注射2毫克/千克和6毫克/千克的利多卡因以及静脉注射3毫克/千克和10毫克/千克的苯妥英钠会同时使血压、心率和呼吸频率升高，并伴有兴奋症状，静脉注射更高剂量（6毫克/千克）的利多卡因会引起惊厥。静脉注射0.1毫克/千克和0.3毫克/千克的维拉帕米会引起心动过速，但无严重神经学效应。在清醒的健康犬中，很少能观察到抗心律失常药物的心血管抑制作用。
