Study-to-Clinic Transition and Daily Oral PrEP Access Experiences Among AGYW in Eastern Cape, South Africa: Insights from the Community PrEP Study.

Adolescent girls and young women (AGYW) face a high HIV burden, while PrEP persistence often declines post-trial. Understanding access outside research settings is key to improving study-to-clinic transitions. This study explored AGYW's experiences accessing PrEP in public clinics after The Community PrEP Study (CPS) in Eastern Cape, South Africa, a 24-month behavioral intervention. AGYW referred to clinics post-study (June-November 2021) were interviewed on their transition experiences. Interviewers categorized participants as PrEP continuation, discontinuation, or non-presentation. The qualitative team iteratively coded transcripts, used matrix analysis and discussions to examine referral experiences, clinic access, and PrEP motivations. While most accepted the transition, many missed study support. Continuation was linked to clinic adaptation, while discontinuation stemmed from access barriers. Non-presentation resulted from logistical and privacy concerns. Recommendations included youth-friendly provider training, alternative PrEP pick-up options, and service integration. Provider engagement and training remain critical for optimizing PrEP access, even with long-acting modalities.Trial registration number NCT03977181. Date of registration: 6 June 2019 - retrospectively registered.