Ma Xiaobo, Mi Fang, Geng Pengfei, Chen Guotong, Zhang Shan, Sun Zhiyuan, Sun Jian, Chen Peng, Guan Ming
College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China.
College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China.
Mikrochim Acta. 2025 Apr 17;192(5):305. doi: 10.1007/s00604-025-07165-2.
Multifunctional nanocomposites have attracted extensive attention in the design of new SERS substrates. In this work, a metal-organic framework (MOF) modified with Ag nanoparticles (Ag NPs) and cysteine functionalized FeO (UiO-66-NH/FeO/Ag) was prepared as a SERS substrate (UFAs). The substrate combines the enrichment ability of UiO-66-NH, the magnetic separation ability of FeO, and the localized surface plasmon resonance (LSPR) effect of Ag NPs to achieve efficient detection of the target analyte. The results of adsorption kinetics showed that the adsorption process of malachite green (MG) was mainly dominated by chemical adsorption. In addition, we further explored the detection mechanism of UFAs for MG. UFAs enriched cation analytes such as MG through π-π stacking and electrostatic interaction and performed SERS detection. The UFA SERS substrate exhibits good detection sensitivity for MG, with a limit of detection (LOD) of 1.35 × 10 M (at 1619 cm), and the SERS substrate has good uniformity and stability. The SERS substrate was applied to the detection of MG in aquaculture water. The recovery of MG in the sample was 91.2-105%, and the relative standard deviation (RSD) was 3.76-6.06%. This high-performance UFA SERS substrate also has great potential for the detection of food and other environmental pollutants in practical applications.
多功能纳米复合材料在新型表面增强拉曼光谱（SERS）基底的设计中受到了广泛关注。在本工作中，制备了一种用银纳米颗粒（Ag NPs）修饰且半胱氨酸功能化的FeO的金属有机框架（MOF）（UiO-66-NH/FeO/Ag）作为SERS基底（UFAs）。该基底结合了UiO-66-NH的富集能力、FeO的磁分离能力以及Ag NPs的局域表面等离子体共振（LSPR）效应，以实现对目标分析物的高效检测。吸附动力学结果表明，孔雀石绿（MG）的吸附过程主要由化学吸附主导。此外，我们进一步探究了UFAs对MG的检测机理。UFAs通过π-π堆积和静电相互作用富集MG等阳离子分析物并进行SERS检测。UFA SERS基底对MG表现出良好的检测灵敏度，检测限（LOD）为1.35×10⁻⁸ M（在1619 cm⁻¹处），且该SERS基底具有良好的均匀性和稳定性。将该SERS基底应用于水产养殖水中MG的检测。样品中MG的回收率为91.2 - 105%，相对标准偏差（RSD）为3.76 - 6.06%。这种高性能的UFA SERS基底在实际应用中对食品和其他环境污染物的检测也具有巨大潜力。
