Torres-Sánchez Luisa, Hernández-Pérez Jesús Gibran, Lopez David S, Romero-Romero Sara, López-Carrillo Lizbeth, Rodríguez-Dorantes Mauricio, Vázquez-Salas Ruth Argelia
Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca, Morelos, México.
School of Public Health of Mexico, Cuernavaca, Morelos, México.
J Expo Sci Environ Epidemiol. 2025 Apr 16. doi: 10.1038/s41370-025-00772-4.
Personal care products (PCPs) use has been associated with a high risk of hormone-sensitive cancers in women. However, this association is poorly understood in hormone-sensitive cancers in men.
To investigate the association between PCPs use and prostate cancer (PC) and PC histological differentiation in men from Mexico City.
We analyzed the information from 400 histologically confirmed incident PC cases and 801 population controls matched by age (±5 y). The usage frequency (daily, weekly, or less, and non-use) of deodorant, body lotion, shampoo, perfume, and shaving or after-shaving products was evaluated based on a structured questionnaire. Using the K-means approach, we selected three patterns according to the usage frequency and number of PCPs used: high, intermediate, and low. Multivariable non-conditional logistic regression models adjusted by selected confounders were conducted to estimate the association between the use of PCPs (patterns, individual products, and number of products used daily) and PC, as well as PC histological differentiation.
Compared to the low exposure pattern, the high (OR: 2.6 95% CI: 1.8-3.8) and intermediate (OR: 1.3 95% CI: 1.0-1.8) PCPs patterns were associated with higher odds of PC. Similarly, the intermediate exposure pattern was significantly associated with poorly differentiated PC (OR: 1.8 95% CI: 1.1-2.9). The daily use of perfume was the most consistent PCP associated with PC (OR : 1.9 95% CI: 1.3-2.8; p for trend = 0.001) and PC poor differentiation (OR: 2.0, 95% CI: 1.1-3.6; p for trend = 0.013). In addition, a dose-response relationship was observed with the number of personal care products used daily.
This study provided evidence that high exposure to personal care products (PCPs) is associated with prostate cancer. Our findings are consistent with those observed regarding hormone-sensitive female cancer and suggest the potential contribution of PCPs to prostatic carcinogenesis.
个人护理产品（PCPs）的使用与女性激素敏感性癌症的高风险相关。然而，在男性激素敏感性癌症中，这种关联尚不清楚。
调查墨西哥城男性使用个人护理产品与前列腺癌（PC）及PC组织学分化之间的关联。
我们分析了400例经组织学确诊的新发PC病例和801名年龄匹配（±5岁）的人群对照的信息。根据一份结构化问卷评估除臭剂、身体乳液、洗发水、香水以及剃须或剃须后产品的使用频率（每日、每周或更少，以及不使用）。使用K均值方法，我们根据使用频率和使用的PCP数量选择了三种模式：高、中、低。进行了经选定混杂因素调整的多变量非条件逻辑回归模型，以估计PCP使用（模式、单个产品以及每日使用的产品数量）与PC以及PC组织学分化之间的关联。
与低暴露模式相比，高（比值比：2.6，95%置信区间：1.8 - 3.8）和中（比值比：1.3，95%置信区间：1.0 - 1.8）PCP模式与PC的较高发病几率相关。同样，中暴露模式与低分化PC显著相关（比值比：1.8，95%置信区间：1.1 - 2.9）。每日使用香水是与PC最一致相关的PCP（比值比：1.9，95%置信区间：1.3 - 2.8；趋势p值 = 0.00）以及与PC低分化相关（比值比：2.0，95%置信区间：1.1 - 3.6；趋势p值 = 0.013）。此外，观察到与每日使用的个人护理产品数量存在剂量反应关系。
本研究提供了证据表明高暴露于个人护理产品（PCPs）与前列腺癌相关。我们的发现与在激素敏感性女性癌症中观察到的结果一致，并提示PCPs对前列腺癌发生的潜在作用。
