Sakano Yuta, Hashimoto Shotaro, Abe Toyofumi, Yamazaki Kaoru, Kidaka Saki, Katsura Satoshi, Okumura Taro, Goto Kenichi, Kosaka Shuhei, Morimoto Masato, Fujita Shigeki, Shigematsu Michio
Department of Respirology Sumitomo Hospital Osaka Japan.
Department of Thoracic Surgery Sumitomo Hospital Osaka Japan.
Respirol Case Rep. 2025 Apr 15;13(4):e70176. doi: 10.1002/rcr2.70176. eCollection 2025 Apr.
Diffuse pulmonary meningotheliomatosis (DPM) is a benign pulmonary disease characterised by widespread bilateral minute pulmonary meningothelial-like nodules that often appear as multiple ground-glass nodules on chest imaging. We present the case of a 64-year-old man with prostate cancer who was found to have multiple pulmonary nodules during cancer staging and was initially suspected to have lung metastases. A surgical lung biopsy confirmed the diagnosis of DPM, allowing the patient to receive curative treatment for localised prostate cancer. DPM is a rare condition reported to be possibly associated with malignancy; however, little is known about its pathogenesis. This case demonstrates the importance of considering DPM in the differential diagnosis of multiple pulmonary nodules, including lung metastases, and the need for further research.
弥漫性肺脑膜瘤病(DPM)是一种良性肺部疾病,其特征是双侧广泛分布的微小肺脑膜上皮样结节,在胸部影像学上常表现为多个磨玻璃结节。我们报告一例64岁前列腺癌男性患者,在癌症分期时发现有多个肺结节,最初怀疑有肺转移。手术肺活检确诊为DPM,使患者能够接受局限性前列腺癌的根治性治疗。DPM是一种罕见疾病,据报道可能与恶性肿瘤有关;然而,对其发病机制知之甚少。该病例表明在鉴别诊断多个肺结节(包括肺转移瘤)时考虑DPM的重要性,以及进一步研究的必要性。