Lins Serafim Joan, Lucas Santos de Menezes Teles Pedro, Souza Lima Amanda Katharinne, Dos Santos Coelho Jéssica, Luna Maranhão Conrado Paloma, Luna Valda Lúcia Moreira, Galvão Pauliana Valéria Machado, Conrado George Alessandro Maranhão
Universidade de Pernambuco RecifePE Brazil Universidade de Pernambuco, Recife, PE, Brazil.
Rev Bras Ginecol Obstet. 2025 Mar 17;47. doi: 10.61622/rbgo/2025rbgo2. eCollection 2025.
Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.
他汀类药物是治疗高脂血症最广泛使用的一类药物，尽管在怀孕期间禁用。本研究旨在通过交互式综述来证明他汀类药物在孕妇中的临床效果。在五年内选择了15篇英文或葡萄牙文的原创文章。他汀类药物与胎儿畸形的发生无关，其使用可能有助于预防不良心血管结局，有可能减轻氧化应激和血管生成功能障碍。然而，他汀类药物在人类中预防先兆子痫的应用尚未得到充分阐明，需要进一步研究。普伐他汀在孕期使用被认为比其他他汀类药物更安全。
