a "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.
b Department of Clinical Biochemistry , University College London Medical School, University College London (UCL) , London , UK.
Expert Opin Investig Drugs. 2018 May;27(5):427-435. doi: 10.1080/13543784.2018.1465927. Epub 2018 Apr 26.
Statins have several pleiotropic effects that have the potential to be beneficial during pregnancy. This study evaluates the available evidence for the teratogenicity of statins, and their utility in treating preeclampsia and dyslipidemia in pregnancy, as good alternatives in these domains are currently lacking.
The possible teratogenicity of statins is a primary focus of this paper. We also evaluated for some possible non-teratogenic effects, such as changes in birth weight and rates of spontaneous abortion, among mothers exposed to statins during pregnancy. Regarding potential uses, this study mainly discusses statin utility in preventing and treating preeclampsia and treating dyslipidemia in pregnancy. Within the latter, we explore the relationship between dyslipidemia and preeclampsia, the potential consequences of delaying statin therapy where indicated, and the impact of supra-physiological levels of cholesterol in utero on offspring. The literature search was conducted using Embase, Web of Science, PubMed, and Scopus.
Based on current evidence, statins are likely not teratogenic. Limited, but promising evidence exists for their efficacy in treating and preventing preeclampsia. In utero exposure to high cholesterol may negatively impact offspring, and should be thoroughly investigated.
他汀类药物具有多种多效作用，有可能在怀孕期间带来益处。本研究评估了他汀类药物的致畸性及其在治疗妊娠子痫前期和血脂异常方面的应用，因为目前这些领域缺乏良好的替代药物。
他汀类药物可能的致畸性是本文的主要关注点。我们还评估了母亲在怀孕期间暴露于他汀类药物时，可能产生的非致畸性影响，如出生体重和自然流产率的变化。关于潜在用途，本研究主要讨论了他汀类药物在预防和治疗子痫前期以及治疗妊娠血脂异常方面的应用。在后者中，我们探讨了血脂异常与子痫前期的关系、在需要时延迟他汀类药物治疗的潜在后果，以及胎儿体内胆固醇水平过高对后代的影响。文献检索使用了 Embase、Web of Science、PubMed 和 Scopus。
根据目前的证据，他汀类药物不太可能致畸。有限但有前景的证据表明，它们在治疗和预防子痫前期方面具有疗效。胎儿暴露于高胆固醇可能会对后代产生负面影响，应进行深入研究。
