Iorra Fernando de Quadros, Rodrigues Paula Godinho, Bock Patrícia Martins, Guahnon Marina Petrasi, Eller Sarah, de Oliveira Tiago Franco, Birk Leticia, Schwarz Patricia de Souza, Drehmer Michele, Bloch Katia V, Cureau Felipe Vogt, Schaan Beatriz D
Postgraduate Program in Medical Sciences: Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre 90035-903, Brazil.
School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90035-903, Brazil.
J Endocr Soc. 2025 Apr 5;9(5):bvaf055. doi: 10.1210/jendso/bvaf055. eCollection 2025 May.
Trimethylamine N-oxide (TMAO) is a metabolite derived from gut microbiota that has been associated with cardiovascular and metabolic disease risk in adults. However, its role in assessing cardiometabolic risk in adolescents is unclear.
This study investigates the association between serum TMAO levels and cardiometabolic health indicators in Brazilian adolescents.
This is a multicenter, cross-sectional analysis involving 4446 participants aged 12 to 17 years from four Brazilian cities. Serum TMAO levels were quantified using liquid chromatography-tandem mass spectrometry, and associations with clinical, metabolic, and inflammatory variables were evaluated through multivariate linear regression analyses.
After adjusting for potential confounders, being in the highest tertile of serum TMAO was positively associated with waist circumference [β 1.45; 95% confidence interval (CI) 0.77, 2.14; < .001], body mass index Z-score (β .19; 95% CI 0.10, 0.27; < .001), and C-reactive protein (β .24; 95% CI 0.13, 0.34; < .001). A negative association between the highest tertile of TMAO and fasting plasma glucose was also observed (β -1.22; 95% CI -1.77, -0.66; < .001).
TMAO may serve as an emerging biomarker for cardiometabolic risk assessment in adolescents.
氧化三甲胺（TMAO）是一种源自肠道微生物群的代谢产物，与成人的心血管和代谢疾病风险相关。然而，其在评估青少年心脏代谢风险中的作用尚不清楚。
本研究调查巴西青少年血清TMAO水平与心脏代谢健康指标之间的关联。
这是一项多中心横断面分析，涉及来自巴西四个城市的4446名12至17岁的参与者。使用液相色谱-串联质谱法定量血清TMAO水平，并通过多元线性回归分析评估其与临床、代谢和炎症变量的关联。
在调整潜在混杂因素后，血清TMAO处于最高三分位数与腰围呈正相关[β 1.45；95%置信区间（CI）0.77，2.14；P <.001]、体重指数Z评分（β 0.19；95%CI 0.10，0.27；P <.001）和C反应蛋白（β 0.24；95%CI 0.13，0.34；P <.001）。还观察到TMAO最高三分位数与空腹血糖之间呈负相关（β -1.22；95%CI -1.77，-0.66；P <.001）。
TMAO可能成为青少年心脏代谢风险评估的一种新兴生物标志物。
