Wang Boya, Guo Xinrui, Qin Lanhui, He Liheng, Li Jingnan, Jin Xudong, Chen Dapeng, Ge Guangbo
Department of Comparative Medicine, Dalian Medical University, Dalian, Liaoning, 116044, China.
Department of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
J Pharm Anal. 2025 Apr;15(4):101074. doi: 10.1016/j.jpha.2024.101074. Epub 2024 Aug 18.
Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal disease, and has become a major global health issue. Individuals with IBD face an elevated risk of developing colorectal cancer (CRC), and recent studies have indicated that mitochondrial dysfunction plays a pivotal role in the pathogenesis of both IBD and CRC. This review covers the pathogenesis of IBD and CRC, focusing on mitochondrial dysfunction, and explores pharmacological targets and strategies for addressing both conditions by modulating mitochondrial function. Additionally, recent advancements in the pharmacological modulation of mitochondrial dysfunction for treating IBD and CRC, encompassing mitochondrial damage, release of mitochondrial DNA (mtDNA), and impairment of mitophagy, are thoroughly summarized. The review also provides a systematic overview of natural compounds (such as flavonoids, alkaloids, and diterpenoids), Chinese medicines, and intestinal microbiota, which can alleviate IBD and attenuate the progression of CRC by modulating mitochondrial function. In the future, it will be imperative to develop more practical methodologies for real-time monitoring and accurate detection of mitochondrial function, which will greatly aid scientists in identifying more effective agents for treating IBD and CRC through modulation of mitochondrial function.
炎症性肠病（IBD）是一种慢性复发性肠道疾病，已成为全球主要的健康问题。IBD患者患结直肠癌（CRC）的风险升高，最近的研究表明，线粒体功能障碍在IBD和CRC的发病机制中起关键作用。本综述涵盖IBD和CRC的发病机制，重点关注线粒体功能障碍，并探讨通过调节线粒体功能来解决这两种疾病的药理学靶点和策略。此外，还全面总结了用于治疗IBD和CRC的线粒体功能障碍药理学调节方面的最新进展，包括线粒体损伤、线粒体DNA（mtDNA）释放和线粒体自噬受损。该综述还系统概述了天然化合物（如黄酮类、生物碱和二萜类）、中药和肠道微生物群，它们可通过调节线粒体功能来缓解IBD并减缓CRC的进展。未来，开发更实用的方法用于实时监测和准确检测线粒体功能势在必行，这将极大地帮助科学家通过调节线粒体功能来识别更有效的治疗IBD和CRC的药物。
