线粒体功能障碍在炎症性肠病和结直肠癌中的作用。
The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer.
机构信息
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Al. Powstańców Wlkp., 70-111 Szczecin, Poland.
Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, Belarus.
出版信息
Int J Mol Sci. 2021 Oct 28;22(21):11673. doi: 10.3390/ijms222111673.
Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease-colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed.
炎症性肠病（IBD）是一种主要的肠道慢性炎症性疾病，尤其在西方国家更为普遍。最近的研究表明，线粒体在 IBD 的发展和向更严重的疾病-结直肠癌（CRC）的进展中起着关键作用。在这篇综述中，我们重点讨论了线粒体突变和功能障碍在 IBD 和 CRC 中的作用。此外，还讨论了涉及 IBD 向 CRC 转化的主要线粒体相关分子途径。此外，还讨论了最近专门针对线粒体靶向治疗方法治疗 IBD 和预防 CRC 进展的出版物。
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