Tang Mengyao, Chen Xiuxia, Liu Linger, Chen Baisong, Han Wenwen, Zhao Xiaofeng, Chen Yao
Department of Internal Medicine, School of Medicine, Shaoxing University, Shaoxing, Zhejiang 312000, P.R. China.
Department of Pathology, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang 311800, P.R. China.
Oncol Lett. 2025 Apr 7;29(6):278. doi: 10.3892/ol.2025.15024. eCollection 2025 Jun.
Synchronous multiple squamous cell carcinomas (SCCs) of the stomach, skin and gingiva are very rare. A 67-year-old male patient was admitted to hospital with progressive chest tightness and fatigue, accompanied by melena. Gastric and dermal biopsies revealed SCCs, and it was considered that triple primary SCCs of the skin, stomach and gingiva had metastasized to the cerebrum, liver, lung, spleen, kidney, bone and subcutaneous tissue. The patient received one cycle of camrelizumab, carboplatin and nab-paclitaxel, followed by two cycles of camrelizumab monotherapy and best supporting care. However, his performance status deteriorated, and he had a very poor survival outcome, succumbing 3 months after diagnosis. Discriminating pathologically between synchronous SCCs in individual organs as metastases or primaries is challenging. In the present case, a diagnosis of triple primary SCCs of the skin, stomach and gingiva with multiple organ metastases was made based on epidemiologic features and clinical presentation. The results of the present case report suggested that anti-programmed death 1 antibodies combined with platinum-based chemotherapy may be a treatment option for metastatic SCC.
胃、皮肤和牙龈同时发生的多发性鳞状细胞癌（SCC）非常罕见。一名67岁男性患者因进行性胸闷和乏力入院，伴有黑便。胃和皮肤活检显示为SCC，考虑皮肤、胃和牙龈的三原发性SCC已转移至大脑、肝脏、肺、脾脏、肾脏、骨骼和皮下组织。该患者接受了一个周期的卡瑞利珠单抗、卡铂和白蛋白结合型紫杉醇治疗，随后进行了两个周期的卡瑞利珠单抗单药治疗及最佳支持治疗。然而，他的体能状态恶化，生存结局很差，确诊后3个月死亡。从病理上区分单个器官中的同步SCC是转移瘤还是原发性肿瘤具有挑战性。在本病例中，基于流行病学特征和临床表现，诊断为皮肤、胃和牙龈的三原发性SCC伴多器官转移。本病例报告结果提示，抗程序性死亡1抗体联合铂类化疗可能是转移性SCC的一种治疗选择。
