一名患者红细胞的N和U抗原呈阴性，但出现了具有临床意义的抗-N。
A clinically significant anti-N in a patient whose red cells were negative for N and U antigens.
作者信息
Ballas S K, Dignam C, Harris M, Marcolina M J
出版信息
Transfusion. 1985 Jul-Aug;25(4):377-80. doi: 10.1046/j.1537-2995.1985.25485273821.x.
Abstract
A patient with sickle cell anemia had M+N-S-s-U-phenotype and developed anti-E, anti-U, and anti-N after multiple transfusions. The anti-N was IgG, showed positive red cell mononuclear phagocyte assay, caused shortened survival of 51Cr-labeled N+ red cells, and incited a delayed hemolytic transfusion reaction. The anti-U also caused decreased survival of U+ cells. The serological findings indicated that the anti-N recognized both N and 'N' antigens.
摘要
一名镰状细胞贫血患者具有M+N-S-s-U-表型，在多次输血后产生了抗-E、抗-U和抗-N。抗-N为IgG，红细胞单核吞噬细胞试验呈阳性，导致51Cr标记的N+红细胞存活时间缩短，并引发了迟发性溶血性输血反应。抗-U也导致U+细胞存活时间缩短。血清学检查结果表明，抗-N识别N和“N”抗原。
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