Zhang Qin, Zhou Qiaoling, Li Huihui
Department of Nephropathy, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P.R. China.
Department of Nephropathy, Xiangya Hospital Central‑South University, Changsha, Hunan 410028, P.R. China.
Mol Med Rep. 2025 Jul;32(1). doi: 10.3892/mmr.2025.13539. Epub 2025 Apr 17.
Neferine is a bisbenzylisoquinoline alkaloid derived from the seed embryo of , a traditional Chinese medicine. It has been extensively studied for its therapeutic potential in various disease models. Extensive research has highlighted its diverse pharmacological activities, including antitumor, anti‑inflammatory, anti‑fibrosis, anti‑oxidative stress, anti‑platelet aggregation and anti‑arrhythmic effects. The present review, however, focuses on the anti‑inflammatory properties of neferine, emphasizing its fundamental mechanisms as demonstrated in both and studies. By critically evaluating its effect on inflammation and the underlying pathways, this review aims to provide a comprehensive understanding of the potential of neferine in the management of inflammatory diseases. Furthermore, it seeks to establish a foundational framework for the future development of neferine as a novel therapeutic agent for inflammatory conditions.
甲基莲心碱是一种从传统中药莲子心种子胚中提取的双苄基异喹啉生物碱。它在各种疾病模型中的治疗潜力已得到广泛研究。大量研究突出了其多样的药理活性，包括抗肿瘤、抗炎、抗纤维化、抗氧化应激、抗血小板聚集和抗心律失常作用。然而，本综述聚焦于甲基莲心碱的抗炎特性，着重阐述其在细胞和动物研究中所证实的基本机制。通过严格评估其对炎症及潜在途径的影响，本综述旨在全面理解甲基莲心碱在炎症性疾病治疗中的潜力。此外，它试图为甲基莲心碱作为炎症性疾病新型治疗药物的未来发展建立一个基础框架。
