Wei Gang, Shen Feng-Jie, Liu Jun-Li, Zhao Jian-Hua, Xie Rong-Rong, Lu Jing, Zhang Chen-Yang, Wang Yuan, Shi Ting-Ting, Yang Fang-Yuan, Chen Shu-Qin, Huang Yan-Jie, Yang Jin-Kui
Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
J Food Sci. 2025 Apr;90(4):e70161. doi: 10.1111/1750-3841.70161.
Ganoderma mushrooms are popularly used as dietary supplements to promote health around the world. However, their potential applications for the prevention and treatment of obesity needs to be further investigated. In this study, we isolated a novel triterpenoid from Ganoderma resinaceum, Resinacein S (Res S), and determined its absolute configuration. We reported that Res S treatment significantly inhibited the high-fat HF diet-induced body weight gain though increased thermogenesis and energy metabolism. Specifically, treatment with Res S promoted brown adipose tissue activation and browning of inguinal white adipose tissue, improving whole-body glucose and lipid homeostasis. Mechanistically, Res S treatment induced the expression of thermogenic genes and related protein, for example, uncoupling protein 1 and mitochondrial biogenesis in a cell-autonomous manner by activating the AMPK-PGC1α signaling pathway. These findings identify Res S as a potential therapeutic alternative for obesity in the setting of its increasingly high prevalence. HIGHLIGHTS: Resinacein S (Res S) exhibited potent anti-obesity effects in high-fat diet-fed mice; Res S treatment significantly promoted brown adipose tissue activation and browning of inguinal white adipose tissue; Res S treatment stimulated UCP1 expression and enhanced mitochondrial function; Res S induced adipocyte thermogenic activity through activating the AMPK-PGC1α axis.
灵芝在世界各地被广泛用作促进健康的膳食补充剂。然而，其在预防和治疗肥胖方面的潜在应用仍需进一步研究。在本研究中，我们从树舌灵芝中分离出一种新型三萜类化合物——树舌灵芝素S（Res S），并确定了其绝对构型。我们报道，Res S处理通过增加产热和能量代谢显著抑制高脂（HF）饮食诱导的体重增加。具体而言，Res S处理促进了棕色脂肪组织的激活以及腹股沟白色脂肪组织的褐色化，改善了全身的葡萄糖和脂质稳态。从机制上讲，Res S处理通过激活AMPK-PGC1α信号通路，以细胞自主的方式诱导产热基因和相关蛋白的表达，例如解偶联蛋白1和线粒体生物发生。鉴于肥胖的患病率日益升高，这些发现表明Res S是一种潜在的肥胖治疗替代品。要点：树舌灵芝素S（Res S）在高脂饮食喂养的小鼠中表现出强大的抗肥胖作用；Res S处理显著促进了棕色脂肪组织的激活以及腹股沟白色脂肪组织的褐色化；Res S处理刺激了解偶联蛋白1的表达并增强了线粒体功能；Res S通过激活AMPK-PGC1α轴诱导脂肪细胞产热活性。
