Dmitrenko Olga, Karpova Nataliia, Nurbekov Malik
Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.
Int J Mol Sci. 2025 Mar 25;26(7):2967. doi: 10.3390/ijms26072967.
Preeclampsia (PE) and gestational diabetes mellitus (GDM) are common pregnancy disorders with shared pathophysiological mechanisms. This study examined the association between SIRT1 polymorphisms (rs12778366 and rs7895833) and relative telomere length (RTL) in women with PE and GDM. The DNA from pregnant women with GDM with and without PE was analyzed. The RTL and genotyping were measured using quantitative real-time PCR. The women with GDM and PE had significantly shorter telomeres. The rs12778366 TC genotype was associated with a 4.48-fold increased risk of PE (OR = 4.48; 95% CI 1.54-13.08; = 0.003). The PE group had a higher prevalence of the heterozygous TC rs12778366 genotype with short telomeres. The SIRT1 variant rs12778366 is associated with shorter telomeres and an increased risk of developing preeclampsia, suggesting it may be a useful biomarker for preeclampsia risk assessment in GDM pregnancies.
子痫前期（PE）和妊娠期糖尿病（GDM）是具有共同病理生理机制的常见妊娠疾病。本研究探讨了PE和GDM女性中SIRT1基因多态性（rs12778366和rs7895833）与相对端粒长度（RTL）之间的关联。分析了患有和未患有PE的GDM孕妇的DNA。使用定量实时PCR测量RTL和基因分型。患有GDM和PE的女性端粒明显更短。rs12778366 TC基因型与PE风险增加4.48倍相关（OR = 4.48；95% CI 1.54 - 13.08；P = 0.003）。PE组中杂合子TC rs12778366基因型且端粒短的患病率更高。SIRT1变体rs12778366与较短的端粒以及子痫前期发生风险增加相关，表明它可能是GDM妊娠子痫前期风险评估的有用生物标志物。
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