锌指蛋白831基因的rs259983多态性增加妊娠期糖尿病女性发生子痫前期的风险。
Polymorphism rs259983 of the Zinc Finger Protein 831 Gene Increases Risk of Superimposed Preeclampsia in Women with Gestational Diabetes Mellitus.
作者信息
Karpova Nataliia, Dmitrenko Olga, Nurbekov Malik
机构信息
Federal State Scientific Institution "Research Institute of General Pathology and Pathophysiology," the Russian Academy of Medical Sciences, 125315 Moscow, Russia.
出版信息
Int J Mol Sci. 2024 Oct 16;25(20):11108. doi: 10.3390/ijms252011108.
Hypertensive disorders of pregnancy (HDP) are a great danger. A previous GWAS found a relationship between rs259983 of the ZNF831 gene and HDP, such as for chronic hypertension (CHTN) and preeclampsia (PE). We conducted the case-control study to determine the association between rs259983 of the ZNF831 gene and HDP in women with Gestational Diabetes Mellitus (GDM). For target genotyping, we developed primers and TaqMan probes. In analyzing the population, we did not manage to find a relationship between PE and rs259983 of the ZNF831 gene. Additional study of women with PE and PE superimposed on CHTN (SIPE) establishes an association between rs259983 of the ZNF831 gene only with SIPE. Carriers of CC genotypes have been discovered to have a 5.05 times higher risk of SIPE development in women with GDM.
妊娠期高血压疾病（HDP）是一大危险因素。先前的一项全基因组关联研究（GWAS）发现ZNF831基因的rs259983与HDP有关，如慢性高血压（CHTN）和子痫前期（PE）。我们开展了病例对照研究，以确定ZNF831基因的rs259983与妊娠期糖尿病（GDM）女性的HDP之间的关联。对于目标基因分型，我们设计了引物和TaqMan探针。在分析人群时，我们未能发现PE与ZNF831基因的rs259983之间存在关联。对患有PE以及PE合并CHTN（SIPE）的女性进行的进一步研究表明，ZNF831基因的rs259983仅与SIPE有关。已发现CC基因型携带者在患有GDM的女性中发生SIPE的风险高5.05倍。
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