Cocorullo Mario, Stamilla Alessandro, Recchia Deborah, Marturano Maria Concetta, Maci Ludovica, Stelitano Giovanni
Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Int J Mol Sci. 2025 Mar 31;26(7):3247. doi: 10.3390/ijms26073247.
() is an opportunistic pathogen gaining increased importance due to its capacity to colonize the respiratory tract of patients with chronic lung diseases such as individuals with Cystic Fibrosis. The actual therapeutic regimen to treat infections is based on repurposed drugs from therapies against and . In addition to the need for new specific drugs against this bacterium, a possible strategy for shortening the therapeutic time and improving the success rate could be targeting virulence factors. These drugs could become an important integration to the actual therapeutic regimen, helping the immune system to fight the infection. Moreover, this strategy applies a low selective pressure on the bacteria, since these elements are not essential for survival but crucial for establishing the infection. This review aims to provide an overview of the 's virulence factors that are poorly studied and mostly unknown, suggesting some interesting alternatives to classical drug development.
（）是一种机会致病菌，由于其能够在慢性肺部疾病患者（如囊性纤维化患者）的呼吸道中定殖，其重要性日益增加。治疗该感染的实际治疗方案基于针对[其他两种疾病]治疗所重新利用的药物。除了需要针对这种细菌的新型特异性药物外，缩短治疗时间并提高成功率的一种可能策略是靶向该细菌的毒力因子。这些药物可以成为实际治疗方案的重要补充，帮助免疫系统对抗感染。此外，这种策略对细菌施加的选择压力较低，因为这些因素对该细菌的生存并非必不可少，但对建立感染至关重要。本综述旨在概述对该细菌研究较少且大多未知的毒力因子，提出一些与传统药物开发不同的有趣替代方案。
