Bao Xiaoyu, Wu Jianping
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Crit Rev Food Sci Nutr. 2024 Dec 12:1-46. doi: 10.1080/10408398.2024.2436139.
Antimicrobial resistance (AMR) poses a global public health concern. Recognizing the critical role of bacterial adhesion in pathogenesis of infection, anti-adhesive therapy emerges as a promising approach to impede initial bacterial attachment, thus preventing pathogenic colonization and infection. Natural anti-adhesive agents derived from food sources are generally safe and have the potential to inhibit the emergence of resistant bacteria. This comprehensive review explored diverse natural dietary components exhibiting anti-adhesive activities against several model enteric pathogens, including , , , and three key diarrheagenic (i.e., enterotoxigenic , enteropathogenic , and enterohemorrhagic ). Investigating various anti-adhesive products will advance our understanding of current research of the field and inspire further development of these agents as potential nutraceuticals or adjuvants to improve the efficacy of conventional antibiotics.
抗菌耐药性（AMR）是一个全球公共卫生问题。认识到细菌黏附在感染发病机制中的关键作用，抗黏附疗法成为一种有前景的方法，可阻止细菌的初始附着，从而预防病原体定植和感染。源自食物来源的天然抗黏附剂通常是安全的，并且有可能抑制耐药菌的出现。这篇综述探讨了多种对几种典型肠道病原体具有抗黏附活性的天然膳食成分，这些病原体包括 、 、 以及三种关键的致泻性 （即产肠毒素 、致病性 、肠出血性 ）。研究各种抗黏附产品将增进我们对该领域当前研究的理解，并推动这些制剂作为潜在的营养保健品或佐剂进一步发展，以提高传统抗生素的疗效。
