Poiană Ioana Ruxandra, Burcea Iulia Florentina, Pițuru Silviu-Mirel, Bucur Alexandru
Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Dentomaxillofac Radiol. 2025 Sep 1;54(6):464-472. doi: 10.1093/dmfr/twaf030.
The present study examined the potential use of CT panoramic mandibular indices on cone beam CT (CBCT) for the assessment of bone density in patients with primary and secondary causes of low bone mass.
The study enrolled 104 postmenopausal women and 66 patients with endocrine-related low bone mass (diabetes mellitus, acromegaly, Cushing syndrome), who underwent dual-energy X-ray absorptiometry (DXA) and CBCT scanning. The study assessed the correlation between DXA parameters (lumbar spine, femoral neck, total hip T-score, bone mineral density [BMD], and trabecular bone score [TBS]) and CBCT-derived indices (CT mandibular index superior [CTI(S)], CT mandibular index inferior [CTI(I)], and CT mental index [CTMI]).
Significant correlations were found between the CBCT indices and both quantitative (BMD, T-score) and qualitative (TBS) measures of bone mass. In postmenopausal women, all 3 CBCT indices showed strong correlations with DXA parameters. In secondary endocrine causes, CTMI and CTI(S) were significantly correlated with TBS scores, and CTMI also showed a significant correlation with lumbar BMD.
The study concludes that CTI(S), CTI(I), and CTMI are valuable for assessing bone density and quality in patients with low bone mass, both in primary and secondary osteoporosis related to diabetes mellitus, acromegaly, and Cushing syndrome.
These findings support the use of CBCT as a useful tool for evaluating bone health in the clinical setting and optimizing dental implant result. It is among the first studies to evaluate bone mass quality and quantity in secondary endocrine causes of low bone mass.
本研究探讨锥形束CT（CBCT）上的CT全景下颌骨指数在评估原发性和继发性低骨量患者骨密度方面的潜在应用。
该研究纳入了104名绝经后女性和66名内分泌相关低骨量患者（糖尿病、肢端肥大症、库欣综合征），这些患者均接受了双能X线吸收法（DXA）和CBCT扫描。该研究评估了DXA参数（腰椎、股骨颈、全髋部T值、骨矿物质密度[BMD]和骨小梁骨评分[TBS]）与CBCT衍生指数（上颌CT下颌骨指数[CTI(S)]、下颌CT下颌骨指数[CTI(I)]和颏部CT指数[CTMI]）之间的相关性。
CBCT指数与骨量的定量（BMD、T值）和定性（TBS）测量指标之间均存在显著相关性。在绝经后女性中，所有3个CBCT指数均与DXA参数显示出强相关性。在继发性内分泌病因中，CTMI和CTI(S)与TBS评分显著相关，CTMI与腰椎BMD也显示出显著相关性。
该研究得出结论，CTI(S)、CTI(I)和CTMI对于评估低骨量患者的骨密度和质量具有重要价值，无论是在与糖尿病、肢端肥大症和库欣综合征相关的原发性还是继发性骨质疏松症中。
这些发现支持将CBCT用作临床环境中评估骨骼健康和优化牙种植效果的有用工具。这是首批评估继发性内分泌性低骨量病因中骨量质量和数量的研究之一。
