Elovaara E, Engström K, Nickels J, Aito A, Vainio H
Xenobiotica. 1985 Apr;15(4):299-308. doi: 10.3109/00498258509045364.
Male Wistar rats were exposed (six hours/day, five days/week) to 0, 50, 300 or 600 p.p.m. of ethylbenzene vapour in the air, and killed after 2, 5, 9 or 16 weeks of exposure. After 600 p.p.m., liver-microsomal protein but not cytochrome P-450 concn. was slightly increased; NADPH-cytochrome c reductase was increased maximally by 30% (1.3-fold), 7-ethoxycoumarin O-deethylase (1.8-fold) and UDPG-transferase (2.3-fold). The increase in liver-cytosolic D-glucuronolactone dehydrogenase paralleled the glucuronidation activity (less than or equal to 2-fold). In the kidneys, only 7-ethoxycoumarin O-deethylase (less than or equal to 3.5-fold) and UDPG-transferase (less than or equal to 1.8-fold) showed dose-related increases. Ethylbenzene exposure did not deplete hepatic glutathione (GSH); kidney GSH was slightly increased (less than or equal to 1.3-fold) according to dose. Urine excretion of thioethers was increased with dose, and at 600 p.p.m. was eight times control levels. At 600 p.p.m. there was no increase in serum alanine aminotransferase activity, and liver cells showed slight proliferation of smooth endoplasmic reticulum, slight degranulation and splitting of rough endoplasmic reticulum and enlarged mitochondria, but no necrosis.
将雄性Wistar大鼠暴露于空气中0、50、300或600 ppm的乙苯蒸气中（每天6小时，每周5天），并在暴露2、5、9或16周后处死。在600 ppm之后，肝微粒体蛋白略有增加，但细胞色素P - 450浓度未增加；NADPH - 细胞色素c还原酶最大增加30%（1.3倍），7 - 乙氧基香豆素O - 脱乙基酶（1.8倍）和UDPG - 转移酶（2.3倍）。肝细胞溶质D - 葡萄糖醛酸内酯脱氢酶的增加与葡萄糖醛酸化活性平行（小于或等于2倍）。在肾脏中，只有7 - 乙氧基香豆素O - 脱乙基酶（小于或等于3.5倍）和UDPG - 转移酶（小于或等于1.8倍）呈现剂量相关的增加。乙苯暴露并未耗尽肝脏中的谷胱甘肽（GSH）；肾脏中的GSH根据剂量略有增加（小于或等于1.3倍）。硫醚的尿排泄量随剂量增加，在600 ppm时是对照水平的8倍。在600 ppm时，血清丙氨酸氨基转移酶活性没有增加，肝细胞显示出滑面内质网略有增生、粗面内质网轻微脱颗粒和分裂以及线粒体增大，但没有坏死。
