da Silva Santos Éverton, Uchida Denise Tiemi, Bruschi Marcos Luciano
Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, PR, Brazil.
AAPS PharmSciTech. 2025 Apr 17;26(5):111. doi: 10.1208/s12249-025-03108-5.
Sericin, a silk-derived protein, has emerged as a potential material for Digital Light Processing (DLP) printing, particularly in uses requiring biocompatibility and sustainability. Sericin is a candidate for developing durable and precise 3D-printed structures due to its natural origin and intrinsic properties like film-forming ability and cross-linking potential. Its biocompatibility makes it suitable for medical applications, such as targeted delivery of anticancer drugs or creation of therapeutic supports directly on affected skin, orthodontic and cosmetic biomaterials, disease modulation, wound healing, antioxidant and antimicrobial applications, and regenerative medicine. Additionally, sericin can strengthen and stabilize printed structures while maintaining environmental integrity, aligning with the growing demand for eco-friendly materials in advanced manufacturing. However, formulating sericin-based resins for DLP printing presents challenges, including optimizing cross-linking and curing processes for obtaining desired properties of material. Overcoming these challenges could unlock the full potential of sericin in diverse fields, such as tissue engineering, where biocompatibility and precise structural integrity are critical. This review investigates the potential of sericin-based resins for 3D printing, emphasizing the protein's compatibility with photopolymerizable systems and its capacity to improve the overall performance of DLP-printed materials. Further research is essential to refine sericin-based formulations, enabling their broader application in 3D printing technologies. By examining the unique characteristics of sericin, including its origins and material properties, this review underscores the protein's potential to drive innovation in sustainable manufacturing. Ultimately, sericin offers a viable alternative to synthetic resins and holds promise for advancing both biomedical and environmental applications through innovative 3D printing technologies.
丝胶蛋白是一种源自丝绸的蛋白质，已成为数字光处理（DLP）打印的潜在材料，尤其适用于需要生物相容性和可持续性的用途。由于其天然来源以及诸如成膜能力和交联潜力等固有特性，丝胶蛋白是开发耐用且精确的3D打印结构的候选材料。其生物相容性使其适用于医疗应用，例如抗癌药物的靶向递送或直接在受影响的皮肤上创建治疗载体、正畸和美容生物材料、疾病调节、伤口愈合、抗氧化和抗菌应用以及再生医学。此外，丝胶蛋白可以增强并稳定打印结构，同时保持环境完整性，这与先进制造中对环保材料日益增长的需求相一致。然而，为DLP打印配制基于丝胶蛋白的树脂存在挑战，包括优化交联和固化过程以获得所需的材料性能。克服这些挑战可以释放丝胶蛋白在组织工程等不同领域的全部潜力，在这些领域中生物相容性和精确的结构完整性至关重要。本综述研究了基于丝胶蛋白的树脂用于3D打印的潜力，强调了该蛋白质与光聚合系统的相容性及其改善DLP打印材料整体性能的能力。进一步的研究对于完善基于丝胶蛋白的配方至关重要，这将使其能够在3D打印技术中得到更广泛的应用。通过研究丝胶蛋白的独特特性，包括其来源和材料性能，本综述强调了该蛋白质在推动可持续制造创新方面的潜力。最终，丝胶蛋白为合成树脂提供了一种可行的替代品，并有望通过创新的3D打印技术推进生物医学和环境应用。
