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稀有鮈鲫三个胚胎发育阶段的转录组分析

Transcriptomic profiling of three embryonic development stages in Rare Minnow (Gobiocypris rarus).

作者信息

Zou Xinhua, Wang Chunling, He Yongfeng, Wang Jianwei

机构信息

Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.

University of Chinese Academy of Sciences, Beijing, 100049, China.

出版信息

Sci Data. 2025 Apr 17;12(1):647. doi: 10.1038/s41597-025-04971-4.

DOI:10.1038/s41597-025-04971-4
PMID:40246865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12006319/
Abstract

Rare minnow (Gobiocypris rarus), a model organism with a transparent chorion and sensitivity to chemicals, is widely used in toxicology and developmental biology. This study provides high-quality gene expression profiles of rare minnow embryos at three key developmental stages: blastula, gastrula, and optic rudiment, obtained via next-generation sequencing (NGS). The dataset is essential for studying zygotic genome activation (ZGA) mechanisms, a pivotal event in early embryonic development, and serves as a valuable resource for investigating the impacts of chemicals on embryo development.

摘要

稀有鮈鲫(Gobiocypris rarus)是一种具有透明卵膜且对化学物质敏感的模式生物,广泛应用于毒理学和发育生物学研究。本研究通过下一代测序(NGS)获得了稀有鮈鲫胚胎在三个关键发育阶段(囊胚、原肠胚和视原基)的高质量基因表达谱。该数据集对于研究合子基因组激活(ZGA)机制这一早期胚胎发育中的关键事件至关重要,并且是调查化学物质对胚胎发育影响的宝贵资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/2705504b18f3/41597_2025_4971_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/fb4191fd561d/41597_2025_4971_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/dd95d7dea9e7/41597_2025_4971_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/06cf994224cc/41597_2025_4971_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/844e72655c02/41597_2025_4971_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/2705504b18f3/41597_2025_4971_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/fb4191fd561d/41597_2025_4971_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/c38c8ed380f2/41597_2025_4971_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/35ae5097504d/41597_2025_4971_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/dd95d7dea9e7/41597_2025_4971_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/06cf994224cc/41597_2025_4971_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/844e72655c02/41597_2025_4971_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbde/12006319/2705504b18f3/41597_2025_4971_Fig7_HTML.jpg

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本文引用的文献

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Cell Rep. 2024 Nov 26;43(11):114888. doi: 10.1016/j.celrep.2024.114888. Epub 2024 Nov 1.
2
Embryonic Exposure to Organophosphate Flame Retardants (OPFRs) Differentially Induces Cardiotoxicity in Rare Minnow ().胚胎期暴露于有机磷酸酯阻燃剂(OPFRs)可导致稀有鱲()产生不同程度的心脏毒性。
Environ Sci Technol. 2024 Aug 6;58(31):13648-13657. doi: 10.1021/acs.est.4c01927. Epub 2024 Jul 28.
3
Transcriptomics in Rare Minnow () towards Attenuated and Virulent Grass Carp Reovirus Genotype II Infection.
稀有鮈鲫对草鱼呼肠孤病毒Ⅱ型减毒株和强毒株感染的转录组学研究
Animals (Basel). 2023 Jun 4;13(11):1870. doi: 10.3390/ani13111870.
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Pluripotency factors determine gene expression repertoire at zygotic genome activation.多能性因子决定合子基因组激活时的基因表达谱。
Nat Commun. 2022 Feb 10;13(1):788. doi: 10.1038/s41467-022-28434-1.
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Genomic deciphering of sex determination and unique immune system of a potential model species rare minnow ().稀有鮈鲫这一潜在模式物种性别决定和独特免疫系统的基因组解析
Sci Adv. 2022 Feb 4;8(5):eabl7253. doi: 10.1126/sciadv.abl7253. Epub 2022 Feb 2.
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De novo screening of disease-resistant genes from the chromosome-level genome of rare minnow using CRISPR-cas9 random mutation.利用 CRISPR-cas9 随机突变对稀有鮈鲫染色体水平基因组进行抗病基因从头筛选。
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