Frenoy Pauline, Marques Chloé, Fiolet Thibault, Cano-Sancho German, Severi Gianluca, Mancini Francesca Romana
Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP UMR1018, 94807 Villejuif, France.
LABERCA, Oniris, INRAE, Nantes, France.
Environ Int. 2022 Sep;167:107444. doi: 10.1016/j.envint.2022.107444. Epub 2022 Jul 30.
Exposure to endocrine-disrupting chemicals, like Polybrominated diphenyl ethers (PBDEs), is suspected of playing a role in the occurrence of breast cancer. Moreover, there is growing evidence that food chemical contaminants, especially lipophilic ones such as PBDEs, could interact with different components of the diet. The objective of the present study was to assess the association between dietary intake of PBDEs and breast cancer risk in the French E3N cohort study, and to investigate the potential modification of this association by vegetable oil consumption. The study included 67879 women. Intakes of eight PBDEs were estimated using food consumption data from a validated semi-quantitative food frequency questionnaire, and food contamination levels measured by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES). Cox proportional hazards models were used to estimate Hazard Ratios (HR) and 95% Confidence Intervals (CI) for the association between total PBDEs dietary intake and breast cancer risk. Interaction measures for vegetable oil consumption were estimated on both additive and multiplicative scales. The women were followed for a maximum of 21.4 years, and 5 686 developed an incident breast cancer. A positive linear trend was highlighted between dietary intake of PBDEs in quintile groups and breast cancer risk, borderline with statistical significance (p-trend = 0.06, HR and 95% CI: 1.09 [0.99;1.20]). Interaction measures for vegetable oil consumption were significant in both additive and multiplicative scales. Higher effect sizes of the association were highlighted in high consumers of vegetable oil, i.e. ≥4.6 g/day (HR and 95% CI: 1.23 [1.08; 1.40]), and almost no effect were found in low consumers (HR and 95% CI: 0.97 [0.86; 1.10]). Highlighting such interactions between nutrients and chemicals is crucial to develop efficient dietary recommendations to limit the negative health effects associated with exposure to food chemical contaminants.
接触内分泌干扰化学物质，如多溴二苯醚（PBDEs），被怀疑与乳腺癌的发生有关。此外，越来越多的证据表明，食品化学污染物，尤其是亲脂性污染物，如PBDEs，可能会与饮食中的不同成分相互作用。本研究的目的是在法国E3N队列研究中评估PBDEs的膳食摄入量与乳腺癌风险之间的关联，并研究植物油消费对这种关联的潜在影响。该研究纳入了67879名女性。使用经过验证的半定量食物频率问卷中的食物消费数据估算了8种PBDEs的摄入量，并由法国食品、环境和职业健康与安全局（ANSES）测量了食物污染水平。使用Cox比例风险模型来估计PBDEs总膳食摄入量与乳腺癌风险之间关联的风险比（HR）和95%置信区间（CI）。在相加和相乘尺度上估计了植物油消费的交互作用量度。对这些女性进行了长达21.4年的随访，其中5686人患了新发乳腺癌。在五分位数组中，PBDEs的膳食摄入量与乳腺癌风险之间呈现出显著的正线性趋势（p趋势 = 0.06，HR和95% CI：1.09 [0.99; 1.20]）。植物油消费的交互作用量度在相加和相乘尺度上均具有显著性。在植物油高消费者中，即每天摄入量≥4.6克，该关联的效应量更高（HR和95% CI：1.23 [1.08; 1.40]），而在低消费者中几乎没有发现效应（HR和95% CI：0.97 [0.86; 1.10]）。强调营养素与化学物质之间的这种相互作用对于制定有效的膳食建议以限制与接触食品化学污染物相关的负面健康影响至关重要。
