2型糖尿病患者中高敏C反应蛋白升高与血脂异常：对尼日利亚患者心血管风险预测的意义

Elevated high-sensitivity C-reactive protein and dyslipidaemia in type 2 diabetes mellitus: implications for cardiovascular risk prediction in Nigerian patients.

作者信息

Mohammed Jamila Aminu, Basil Bruno, Mba Izuchukwu Nnachi, Abubakar Nabilah Datti, Lawal Akeem Oyeyemi, Momoh Jafaru Alunua, Yahaya Isah Adagiri

机构信息

Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria.

International Institute of Pathology and Forensic Science Research, David Umahi Federal University of Health Sciences, Uburu, Nigeria.

出版信息

BMC Endocr Disord. 2025 Apr 17;25(1):100. doi: 10.1186/s12902-025-01930-3.

DOI:10.1186/s12902-025-01930-3

PMID:40247255

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12004578/

Abstract

BACKGROUND

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among individuals with type 2 diabetes mellitus (T2DM). Inflammation, marked by elevated high-sensitivity C-reactive protein (hs-CRP) levels, and dyslipidaemia, are critical contributors to atherosclerosis and cardiovascular risk. In Nigeria, where T2DM prevalence is rising, there is a need for more comprehensive risk prediction tools, incorporating both traditional and newer biomarkers such as hs-CRP. This study aimed to investigate the association between elevated hs-CRP levels and dyslipidaemia in Nigerian patients with T2DM and to explore the potential implications for cardiovascular risk prediction.

METHODS

A hospital-based cross-sectional study was conducted among 150 T2DM patients and 150 age-matched controls. Data on socio-demographics, medical history, clinical characteristics, and laboratory parameters, including lipid profiles and hs-CRP levels, were collected. The relationship between hs-CRP levels and lipid parameters was assessed using Pearson's correlation coefficient and independent t-tests.

RESULTS

T2DM patients exhibited significantly higher hs-CRP levels (2.2 ± 1.8 mg/L vs. 1.2 ± 1.0 mg/L, p < 0.001), dyslipidaemia (p < 0.001), and blood pressure (SPB- 127.6 ± 12.4 mmHg, DBP- 77.6 ± 6.6 mmHg vs. SBP- 119.6 ± 10.8 mmHg, DBP- 72.1 ± 8.0 mmHg; p = 0.001) compared to controls. However, no significant correlation was found between hs-CRP levels and lipid parameters.

CONCLUSION

Although no direct association was found between elevated hs-CRP levels and dyslipidaemia, hs-CRP remains an important marker of cardiovascular risk possibly through non-lipid pathways, such as inflammation-driven endothelial dysfunction. Further research is needed to evaluate its potential role in refining cardiovascular risk assessment in the Nigerian T2DM population.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

心血管疾病（CVD）是2型糖尿病（T2DM）患者发病和死亡的主要原因。以高敏C反应蛋白（hs-CRP）水平升高为特征的炎症和血脂异常是动脉粥样硬化和心血管风险的关键因素。在2型糖尿病患病率不断上升的尼日利亚，需要更全面的风险预测工具，纳入传统和新型生物标志物，如hs-CRP。本研究旨在调查尼日利亚T2DM患者hs-CRP水平升高与血脂异常之间的关联，并探讨其对心血管风险预测的潜在影响。

方法

对150例T2DM患者和150例年龄匹配的对照者进行了一项基于医院的横断面研究。收集了社会人口统计学、病史、临床特征和实验室参数数据，包括血脂谱和hs-CRP水平。使用Pearson相关系数和独立t检验评估hs-CRP水平与血脂参数之间的关系。

结果

与对照组相比，T2DM患者的hs-CRP水平（2.2±1.8mg/L对1.2±1.0mg/L，p<0.001）、血脂异常（p<0.001）和血压（收缩压-127.6±12.4mmHg，舒张压-77.6±6.6mmHg对收缩压-119.6±10.8mmHg，舒张压-72.1±8.0mmHg；p=0.001）显著更高。然而，hs-CRP水平与血脂参数之间未发现显著相关性。