Wang Zengwu, Wang Xin, Chen Zuo, Zhang Linfeng, Zhu Manlu
Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China.
Int J Environ Res Public Health. 2016 Aug 31;13(9):872. doi: 10.3390/ijerph13090872.
An increased concentration of high-sensitivity C-reactive protein (hs-CRP) indicates risk for cardiovascular disease (CVD). Because the available data is limited, a cross-sectional survey was conducted in 2009-2010 to describe hs-CRP distribution and its relationship with established CVD risk factors.
A population-based sample of adults aged 35 to 64 years (n = 14,046) was taken from 12 research populations across China. Demographic and clinical characteristics were recorded, and hs-CRP measured. Pearson's and Kendall's tau-b correlation coefficient, and multiple regression analyses were used to test the relationship between hs-CRP and other CVD risk factors.
For 8389 (4412 females) eligible participants, hs-CRP was 1.89 ± 4.37 mg/L (median (25th, 75th): 0.80 (0.40, 1.80)), and increased with age, BP, glucose, and BMI (p < 0.05), males had significantly higher hs-CRP than females (2.07 (4.89) vs. 1.73 (3.83), p < 0.001). About 24.3% had the hs-CRP concentrations more than the top quartile (25.8% in males, 22.9% in females), 12.3% (13.3% in males, 11.5% in females) >3 mg/L. There was a significant positive correlation of quartiles of hs-CRP concentrations with age, SBP, DBP, glucose level, BMI, LDL-C/HDL-C ratio, and LDL-C/total cholesterol ratio (p < 0.001). The elevated hs-CRP (>1.80 mg/L) related positively with age, LDL-C, BP, glucose, BMI, and living north and negatively with HDL-C/TC, LDL-C/TC, TC independently (p < 0.05). For subjects with coexisting hypertension, diabetes, high cholesterol, and obesity, about 63.0% were in the top quartile of hs-CRP concentrations.
Hs-CRP was associated with most of the known CVD risk factors. Measurement of hs-CRP may provide a more comprehensive view of the patient's overall risk profile in the Chinese population.
高敏C反应蛋白（hs-CRP）浓度升高表明存在心血管疾病（CVD）风险。由于现有数据有限，于2009年至2010年进行了一项横断面调查，以描述hs-CRP的分布及其与既定CVD风险因素的关系。
从中国各地的12个研究人群中选取了一个基于人群的35至64岁成年人样本（n = 14,046）。记录人口统计学和临床特征，并测量hs-CRP。使用Pearson和Kendall的tau-b相关系数以及多元回归分析来检验hs-CRP与其他CVD风险因素之间的关系。
对于8389名（4412名女性）符合条件的参与者，hs-CRP为1.89±4.37mg/L（中位数（第25、75百分位数）：0.80（0.40，1.80）），并随年龄、血压、血糖和体重指数增加（p < 0.05），男性的hs-CRP显著高于女性（2.07（4.89）对1.73（3.83），p < 0.001）。约24.3%的人hs-CRP浓度高于上四分位数（男性为25.8%，女性为22.9%），12.3%（男性为13.3%，女性为11.5%）>3mg/L。hs-CRP浓度四分位数与年龄、收缩压、舒张压、血糖水平、体重指数、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值和低密度脂蛋白胆固醇/总胆固醇比值呈显著正相关（p < 0.001）。hs-CRP升高（>1.80mg/L）与年龄、低密度脂蛋白胆固醇、血压、血糖、体重指数以及居住在北方呈正相关，与高密度脂蛋白胆固醇/总胆固醇、低密度脂蛋白胆固醇/总胆固醇、总胆固醇独立呈负相关（p < 0.05）。对于同时患有高血压、糖尿病、高胆固醇和肥胖症的受试者，约63.0%处于hs-CRP浓度的上四分位数。
Hs-CRP与大多数已知的CVD风险因素相关。测量hs-CRP可能为中国人群中患者的总体风险状况提供更全面的了解。
