Profiling of Diagnostic Value of Serum CysC, β2-MG and α-Klotho in Early Acute Kidney Injury Caused by Acute Myocardial Infarction.

OBJECTIVE

To decipher the diagnostic value of serum cystatin C (CysC), β2-microglobulin (β2-MG) and α-Klotho in early acute kidney injury (AKI) caused by acute myocardial infarction (AMI).

METHODS

This study screened 176 eligible patients and established two groups of AKI group (n = 51) and non-AKI group (n = 125). This study measured and compared the serum CysC, β2-MG, α-Klotho, serum creatinine (Scr), blood urea nitrogen (BUN), creatine kinase isoenzymes MB (CK-MB) and cardiac troponin T (cTnI) between the two groups. This study further analyzed correlations of CysC, β2-MG and α-Klotho with Scr and BUN, and the relationship of various indicators with AKI, with receiver operating characteristic (ROC) curves plotted.

RESULTS

AKI group was detected with significant changes in baseline data compared with non-AKI group. Serum CysC, β2-MG and α-Klotho had significantly positive correlations with Scr and BUN. CK-MB, Scr, BUN, CysC, β2-MG, and α-Klotho were independent risk factors for AKI in AMI patients. The AUC, sensitivity, and specificity of CysC for predicting AKI were 0.840, 0.627, and 0.984; which were 0.835, 0.784, and 0.864 for β2-MG; 0.881, 0.824, and 0.832 for α-Klotho; as well as 0.913, 0.843, and 0.880 when using three indicators jointly. Joint detection had better predictive performance for AKI than any single indicator.

CONCLUSION

Serum CysC, β2-MG and α-Klotho are significantly positively correlated with reduced renal function and are independent risk factors for AKI, exhibiting high early diagnostic value for AKI in AMI patients.