Kobylinski S
Zentralbl Allg Pathol. 1985;130(2):125-37.
Descriptions of the nature and pathogenesis of disturbances of the microcirculation induced by intravenous infusion of a triglyceride emulsion or by daily oral administration of a cholesterol-in-oil suspension are different and partially contradictory in the medical literature. Hyperlipemic disturbances of the microcirculation are characterized by a general decrease in the rate of flow reflected in all parameters of flow in the terminal blood vessels including a rise of the number of capillaries temporarily functionally isolated from the circulation and by an increase in capillary plasma skimming. The degree is dependent upon the amount of administered fat and on lipid levels. The disturbed capillary perfusion can be attributed to various rheological mechanisms. The hemodynamical relevance of the short-time hyperlipemia produced by intravenous infusion of a fat emulsion and the enduring hyperlipemia produced by the daily oral administration of a cholesterol-in-oil suspension differ. Some of the capillary-rheological bases of these differences are discussed.
在医学文献中，关于静脉输注甘油三酯乳剂或每日口服油包胆固醇混悬液所引发的微循环障碍的性质和发病机制的描述各异，且部分相互矛盾。高脂血症性微循环障碍的特征是血流速度普遍降低，这反映在末梢血管的所有血流参数上，包括暂时与循环功能隔离的毛细血管数量增加以及毛细血管血浆撇取增加。其程度取决于所给予脂肪的量和血脂水平。毛细血管灌注紊乱可归因于多种流变学机制。静脉输注脂肪乳剂产生的短时高脂血症与每日口服油包胆固醇混悬液产生的持续性高脂血症的血液动力学相关性有所不同。本文讨论了这些差异的一些毛细血管流变学基础。
