Bu Jiarui, Miao Zeyu, Yang Qing
Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China.
Genes Dis. 2024 Jul 2;12(4):101370. doi: 10.1016/j.gendis.2024.101370. eCollection 2025 Jul.
In recent years, the incidence and mortality rates of pancreatic cancer have been steadily increasing, and conventional therapies have shown a high degree of tolerance. Therefore, the search for new therapeutic targets remains a key issue in current research. Mitochondrial glutamic-oxaloacetic transaminase 2 (GOT2) is an important component of the malate-aspartate shuttle system, which plays an important role in the maintenance of cellular redox balance and amino acid metabolism, and has the potential to become a promising target for anti-cancer therapy. In this paper, we will elaborate on the metabolic and immune effects of GOT2 in pancreatic cancer based on existing studies, with a view to opening up new avenues for the treatment of pancreatic cancer.
近年来，胰腺癌的发病率和死亡率一直在稳步上升，而传统疗法已显示出高度的耐受性。因此，寻找新的治疗靶点仍然是当前研究的关键问题。线粒体谷草转氨酶2（GOT2）是苹果酸-天冬氨酸穿梭系统的重要组成部分，在维持细胞氧化还原平衡和氨基酸代谢中起重要作用，并且有潜力成为有前景的抗癌治疗靶点。在本文中，我们将基于现有研究阐述GOT2在胰腺癌中的代谢和免疫作用，以期为胰腺癌的治疗开辟新途径。
