Alyousef Alanoud Maan, Mekawy Doaa Zeinhom, Bashumeel Yaser Yousef, Mohamed Saleh Magdy, Almigbal Turky H, Batais Mohammed A, Alrasheed Abdullah A
Department of Family Medicine, Johns Hopkins Aramco Hospital, Dhahran, Saudi Arabia.
Saudi Family Medicine Board, King Saud University Medical Hospital, Riyadh, Saudi Arabia.
Front Endocrinol (Lausanne). 2025 Apr 3;16:1551201. doi: 10.3389/fendo.2025.1551201. eCollection 2025.
Metabolic syndrome is present in a subset of individuals harboring a constellation of metabolic risk factors that heightens their likelihood of developing coronary artery disease. Non-alcoholic fatty liver disease (NAFLD) manifests through the incremental accumulation of fat within liver cells in the absence of secondary causes. NAFLD has long been recognized as the hepatic manifestation of metabolic syndrome. Our study seeks to ascertain the prevalence of metabolic syndrome among NAFLD patients at King Khalid University Hospital and to explore the factors associated with metabolic syndrome.
We conducted a retrospective study targeting 1,173 patients diagnosed with NAFLD at King Khalid University Hospital in Riyadh, Saudi Arabia, from March 2020 to March 2021. NAFLD diagnosis was made based on ultrasonographic evidence of a fatty liver, excluding other liver ailments and alcohol intake. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria, which require at least three of five metabolic risk factors to be present. Statistical analysis was performed using chi-square tests for categorical variables and independent t-tests for continuous variables, with a significance level set at p < 0.05.
Out of 1173 NAFLD participants evaluated, 38.2% met the NCEP/ATPIII criteria for metabolic syndrome. Additionally, 23.8% had at least one metabolic syndrome component coinciding with their ultrasonographically confirmed NAFLD diagnosis. The incidence of NAFLD was not linked to gender. Married individuals constituted a higher percentage (42.8%) of the NAFLD cohort. Elevated blood glucose and triglyceride levels, along with reduced HDL levels, were predominantly observed among the metabolic syndrome components in NAFLD patients.
A significant portion of the NAFLD patient population was concurrently affected by metabolic syndrome. There exists a marked interrelationship between NAFLD and the components of metabolic syndrome. Regular metabolic disorder screenings are recommended for this patient group.
代谢综合征存在于一部分具有一系列代谢危险因素的个体中，这些因素增加了他们患冠状动脉疾病的可能性。非酒精性脂肪性肝病（NAFLD）通过在无继发原因的情况下肝细胞内脂肪的逐渐积累而表现出来。NAFLD长期以来一直被认为是代谢综合征的肝脏表现。我们的研究旨在确定哈利德国王大学医院NAFLD患者中代谢综合征的患病率，并探索与代谢综合征相关的因素。
我们进行了一项回顾性研究，目标是2020年3月至2021年3月在沙特阿拉伯利雅得哈利德国王大学医院诊断为NAFLD的1173名患者。NAFLD的诊断基于脂肪肝的超声证据，排除其他肝脏疾病和酒精摄入。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP/ATP III）标准定义，该标准要求存在五个代谢危险因素中的至少三个。对分类变量使用卡方检验，对连续变量使用独立t检验进行统计分析，显著性水平设定为p<0.05。
在评估的1173名NAFLD参与者中，38.2%符合代谢综合征的NCEP/ATPIII标准。此外，23.8%的患者在超声证实NAFLD诊断时至少有一个代谢综合征成分。NAFLD的发病率与性别无关。已婚个体在NAFLD队列中占比更高（42.8%）。NAFLD患者代谢综合征成分中主要观察到血糖和甘油三酯水平升高以及高密度脂蛋白水平降低。
很大一部分NAFLD患者同时受到代谢综合征的影响。NAFLD与代谢综合征各成分之间存在明显的相互关系。建议对该患者群体进行定期的代谢紊乱筛查。
