Abraham Dax, Gupta Alpa, Duraisamy Arun Kumar, Mrinalini Mrinalini
Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, School of Dental Sciences, Faridabad, Haryana, 121001, India.
Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences- CAPFIMS Center, New Delhi, 110068, India.
J Oral Biol Craniofac Res. 2025 May-Jun;15(3):612-623. doi: 10.1016/j.jobcr.2025.03.022. Epub 2025 Apr 8.
Chronic periodontitis (CP), a prevalent inflammatory dental disease, has been linked to systemic conditions like Type 2 Diabetes Mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate resistin levels in the Gingival Crevicular Fluid (GCF) of CP individuals with T2DM. The objective was to determine if resistin could be a potential biomarker for periodontal disease in T2DM individuals.
The review included data from seventeen clinical studies that investigated resistin levels in GCF of individuals diagnosed with CP and T2DM. Data were sourced from PubMed, Scopus, and EBSCOhost, selected for their extensive coverage of medical and dental research, ensuring thorough retrieval of relevant studies. From the initial seventeen studies, five complied with the strict inclusion criteria for meta-analysis.
Using a comprehensive meta-analysis, the significance of GCF Resistin levels in individuals with CP and T2DM relative to the healthy groups was examined. In addition, a meta-analysis was carried out to look into the relationship between periodontal probing depth (PPD) and CP and T2DM. The results indicated that individuals with T2DM and CP had significantly higher GCF resistin levels than the other groups. Furthermore, the PPD in T2DM with CP was significantly greater than in the other groups.
The present review highlights the potential role of resistin as a biomarker to diagnose individuals with chronic periodontitis and T2DM.
The significantly elevated levels of resistin suggest that resistin could serve as a potential biomarker for T2DM in individuals with CP. This could lead to improved methods of early diagnosis and treatment, which could enhance individual outcomes and quality of life.
The registration number CRD42023467186.
慢性牙周炎（CP）是一种常见的炎症性牙科疾病，与2型糖尿病（T2DM）等全身性疾病有关。本系统评价和荟萃分析旨在评估合并T2DM的CP患者龈沟液（GCF）中的抵抗素水平。目的是确定抵抗素是否可能成为T2DM患者牙周疾病的潜在生物标志物。
该评价纳入了17项临床研究的数据，这些研究调查了被诊断为CP和T2DM的个体GCF中的抵抗素水平。数据来源于PubMed、Scopus和EBSCOhost，选择这些数据库是因为它们广泛涵盖医学和牙科研究，确保全面检索相关研究。从最初的17项研究中，有5项符合荟萃分析的严格纳入标准。
通过全面的荟萃分析，研究了CP和T2DM个体中GCF抵抗素水平相对于健康组的显著性。此外，还进行了荟萃分析以探讨牙周探诊深度（PPD）与CP和T2DM之间的关系。结果表明，合并T2DM和CP的个体GCF抵抗素水平显著高于其他组。此外，合并CP的T2DM患者的PPD显著大于其他组。
本评价强调了抵抗素作为诊断慢性牙周炎和T2DM个体的生物标志物的潜在作用。
抵抗素水平显著升高表明，抵抗素可能作为CP患者T2DM的潜在生物标志物。这可能会带来改进的早期诊断和治疗方法，从而改善个体预后和生活质量。
PROSPERO注册：注册号CRD42023467186。
