Anderson N E, Willoughby E W, Wrightson P
Acta Neurol Scand. 1985 Jun;71(6):472-9. doi: 10.1111/j.1600-0404.1985.tb03230.x.
A retrospective analysis was made of the natural history and treatment of 44 patients with syringomyelia, followed for a median interval of 10 years after diagnosis. Twenty-four patients were treated surgically. Four of 12 patients who had a laminectomy with aspiration of the syrinx or syringostomy, and 7 of 15 patients who underwent decompression and exploration of the cervicomedullary junction, showed sustained improvement or stabilisation of their neurological deficits. When symptoms had been present for more than 2 years, when there was a moderate or severe neurological disability, and when the patient was more than 40 years old, the long-term outlook of posterior fossa surgery was usually poor. Of the 20 patients who did not have an operation, 7 had no further progression in symptoms after presentation and prolonged survival was usual. It is concluded that in many cases syringomyelia is compatible with prolonged survival, and although improvement can follow surgery, its influence on the disease in the long-term is uncertain.
对44例脊髓空洞症患者的自然病史和治疗情况进行了回顾性分析，诊断后中位随访时间为10年。24例患者接受了手术治疗。12例行椎板切除术并抽吸空洞或行空洞造瘘术的患者中，4例以及15例行颈髓交界处减压及探查术的患者中，7例神经功能缺损持续改善或稳定。当症状出现超过2年、存在中度或重度神经功能障碍以及患者年龄超过40岁时，后颅窝手术的长期预后通常较差。20例未手术的患者中，7例症状出现后未进一步进展，通常生存期延长。结论是，在许多情况下，脊髓空洞症患者可长期存活，尽管手术可能带来改善，但其对疾病的长期影响尚不确定。
