Dussaix E, Lebon P, Ponsot G, Huault G, Tardieu M
Acta Neurol Scand. 1985 Jun;71(6):504-9. doi: 10.1111/j.1600-0404.1985.tb03235.x.
CSF and sera from 238 newborns and children with various neurological diseases were assayed on bovine cells for the presence of alpha-interferon (IFN). An intrathecal synthesis of pH 2-resistant alpha-IFN was recovered in all newborns and in more than 90% of children with herpes encephalitis. It was also observed in one case of mumps encephalitis and in one case of encephalitis associated with Influenza A infection. An acid-labile alpha-IFN production was detected in CSF from more than one half of patients with viral meningitis or active congenital rubella and in those with neurological complications of systemic lupus erythematosus. This alpha-IFN subtype was also detected in CSF from only 2/37 children with measles encephalitis. In contrast, no alpha-IFN (less than 2 IU) in CSF was found among patients with subacute sclerosing panencephalitis, Guillain-Barré syndrome, Reye's syndrome, acute cerebellar ataxia, infantile spasms or facial paralysis of unknown origin.
对238名患有各种神经系统疾病的新生儿和儿童的脑脊液及血清进行检测，以确定牛细胞中是否存在α-干扰素（IFN）。在所有新生儿以及90%以上的疱疹性脑炎患儿中，均检测到鞘内合成的耐pH 2的α-IFN。在1例腮腺炎脑炎和1例甲型流感感染相关的脑炎病例中也观察到了这种情况。在超过一半的病毒性脑膜炎或活动性先天性风疹患者以及系统性红斑狼疮神经并发症患者的脑脊液中检测到了酸不稳定的α-IFN产生。在仅37名麻疹脑炎患儿中的2名患儿的脑脊液中也检测到了这种α-IFN亚型。相比之下，在亚急性硬化性全脑炎、格林-巴利综合征、瑞氏综合征、急性小脑性共济失调、婴儿痉挛症或不明原因的面瘫患者的脑脊液中未发现α-IFN（低于2 IU）。
