神经肿瘤学中的诊断与诊疗一体化机遇。
Diagnostic and theranostic opportunities in Neuro-oncology.
作者信息
Ritter Zsombor, Oeltzschner Georg, Solnes Lilja Bjork, Liu Guanshu, Kamson David Olayinka
机构信息
The Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins Hospital, Baltimore, MD.
Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD.
出版信息
Adv Oncol. 2024 May;4(1):111-124. doi: 10.1016/j.yao.2024.01.001. Epub 2024 Jan 29.
Theranostics, the interlinking of diagnostic and therapeutic procedures, can be particularly valuable in neuro-oncology, addressing the challenges posed by the blood-brain and brain-tumor barriers. While it is traditionally associated with nuclear medicine, advances in MR imaging techniques have opened new theranostic frontiers. This review covers the present challenges in neuro-oncology and how these could be overcome utilizing radioligand-based molecular radiotherapy as well as how label-free theranostics employing methods such as chemical exchange saturation transfer (CEST) and MR spectroscopy could advance the field.
治疗诊断学，即诊断与治疗程序的相互关联，在神经肿瘤学中可能具有特别重要的价值，可应对血脑屏障和脑肿瘤屏障带来的挑战。虽然它传统上与核医学相关，但磁共振成像技术的进步开辟了新的治疗诊断学前沿领域。本综述涵盖了神经肿瘤学目前面临的挑战，以及如何利用基于放射性配体的分子放射疗法来克服这些挑战，还探讨了采用化学交换饱和转移（CEST）和磁共振波谱等方法的无标记治疗诊断学如何推动该领域的发展。
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