Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231208613. doi: 10.1177/15330338231208613.
Chemical exchange saturation transfer (CEST) is a relatively novel magnetic resonance imaging (MRI) technique with an image contrast designed for in vivo measurement of certain endogenous molecules with protons that are exchangeable with water protons, such as amide proton transfer commonly used for neuro-oncology applications. Recent technological advances have made it feasible to implement CEST on clinical grade scanners within practical acquisition times, creating new opportunities to integrate CEST in clinical workflow. In addition, the majority of CEST applications used in neuro-oncology are performed without the use gadolinium-based contrast agents which are another appealing feature of this technique. This review is written for clinicians involved in neuro-oncologic care (nonphysicists) as the target audience explaining what they need to know as CEST makes its way into practice. The purpose of this article is to (1) review the basic physics and technical principles of CEST MRI, and (2) review the practical applications of CEST in neuro-oncology.
化学交换饱和传递（CEST）是一种相对较新的磁共振成像（MRI）技术，其图像对比度旨在用于体内测量某些与水质子可交换的质子的内源性分子，例如酰胺质子转移，常用于神经肿瘤学应用。最近的技术进步使得在临床级扫描仪上在实际采集时间内实现 CEST 成为可能，为将 CEST 整合到临床工作流程中创造了新的机会。此外，神经肿瘤学中使用的大多数 CEST 应用都是在不使用钆基造影剂的情况下进行的，这是该技术的另一个吸引人的特点。本文面向从事神经肿瘤学护理的临床医生（非物理学家）撰写，为 CEST 进入实践提供了他们需要了解的内容。本文的目的是：(1) 综述 CEST MRI 的基本物理和技术原理；(2) 综述 CEST 在神经肿瘤学中的实际应用。
