Tang Zhongyuan, Jin Lijian, Yang Yanqi
Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Division of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Immunol. 2025 Apr 3;16:1578635. doi: 10.3389/fimmu.2025.1578635. eCollection 2025.
Periodontitis is a common dysbiotic bacteria-induced inflammatory disease characterized by alveolar bone resorption, leading to tooth loss. Interleukin-17 (IL-17) is a critical cytokine with dual roles in periodontium, which exerts the function of host defense, including neutrophil recruitment, phagocytosis, and mucosal immunity. However, excessive expression of IL-17 causes persistent chronic inflammation, local tissue breakdown, and bone loss. This review highlights the protective and pathological functions of IL-17 on immunity and bone homeostasis in inflammatory bone-related diseases. We also provide the latest findings with IL-17 knockout mice in periodontitis and highlight complex immune responses under various experimental models. This may provide a critical perception of inflammatory bone-related disease management using an immune-modulating strategy.
牙周炎是一种常见的由微生物群落失调引发的炎症性疾病，其特征为牙槽骨吸收，最终导致牙齿脱落。白细胞介素-17（IL-17）是一种关键细胞因子，在牙周组织中具有双重作用，发挥着宿主防御功能，包括募集中性粒细胞、吞噬作用以及黏膜免疫。然而，IL-17的过度表达会导致持续性慢性炎症、局部组织破坏和骨质流失。本综述着重阐述了IL-17在炎症性骨相关疾病中对免疫和骨稳态的保护及病理作用。我们还介绍了IL-17基因敲除小鼠在牙周炎研究中的最新发现，并强调了各种实验模型下复杂的免疫反应。这可能为采用免疫调节策略治疗炎症性骨相关疾病提供重要的见解。
