Stewart P A, Hayakawa K, Hayakawa E, Farrell C L, Del Maestro R F
Acta Neuropathol. 1985;67(1-2):96-102. doi: 10.1007/BF00688129.
Cerebral edema, a major complication of tumors in the brain, is the result of an alteration in the blood-brain barrier (B-BB). The vascular ultrastructural changes that underlie edema formation have been described in a variety of tumors. Interendothelial junction abnormalities, fenestrations, and large numbers of tubulo-vesicular profiles in the tumor vascular endothelium have been presumed to represent permeability routes that permit the escape of serum constituents into the tumor, from where they flow into the surrounding brain. Descriptive studies do not provide information on the relative frequency of these presumptive permeability routes. In the study reported here we have quantified ultrastructural features associated with the B-BB in the vessels of an experimental glioma in rat. We found that approximately 60% of the tumor vessel profiles have junctional abnormalities and 30% have one or more fenestrations. The density of tubulo-vesicular profiles, however, was not increased. In addition, tumor vessel walls were thicker than normal vessels of the same caliber and the mitochondrial density was in the range of that for non-barrier vessels. Vessels in peritumoral regions were not altered in any of the parameters measured.
脑水肿是脑肿瘤的主要并发症，是血脑屏障（B-BB）改变的结果。在多种肿瘤中已描述了构成水肿形成基础的血管超微结构变化。肿瘤血管内皮细胞间连接异常、窗孔以及大量的微管-小泡结构被认为是血清成分逸出至肿瘤并从肿瘤流入周围脑组织的通透性途径。描述性研究未提供这些推测的通透性途径相对频率的信息。在本文报道的研究中，我们对大鼠实验性胶质瘤血管中与血脑屏障相关的超微结构特征进行了量化。我们发现，约60%的肿瘤血管轮廓存在连接异常，30%有一个或多个窗孔。然而，微管-小泡结构的密度并未增加。此外，肿瘤血管壁比相同管径的正常血管更厚，线粒体密度处于非屏障血管的范围内。肿瘤周围区域的血管在所测量的任何参数中均未改变。
