线粒体DNA 4977碱基对缺失作为重度抑郁症的潜在性状标志物
The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder.
作者信息
He Ying, Yang Xinbo, Li Zongchang, Liu Weiqing, Tang Jinsong, Chen Xiaogang
机构信息
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People's Republic of China.
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, 200122, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2025 Apr 13;21:867-873. doi: 10.2147/NDT.S509050. eCollection 2025.
BACKGROUND
Major depressive disorder (MDD) is significantly influenced by genetic factors. The present study aims to examine the potential correlation between the 4977 bp deletion of mitochondrial DNA (mtDNA) and MDD.
METHODS
The 4977 bp deletion of mtDNA was detected in the peripheral blood of 253 MDD patients and 257 healthy controls, with depression assessed by the Hamilton Depression Rating scale and functioning by the Global Assessment of Function Scale.
RESULTS
MDD patients had a higher incidence of the 4977 bp deletion, unaffected by demographic or clinical factors.
CONCLUSION
The 4977 bp deletion may be a trait marker for MDD.
背景
重度抑郁症（MDD）受遗传因素的影响很大。本研究旨在探讨线粒体DNA（mtDNA）4977bp缺失与MDD之间的潜在关联。
方法
在253例MDD患者和257例健康对照者的外周血中检测mtDNA的4977bp缺失情况，采用汉密尔顿抑郁量表评估抑郁程度，采用功能总体评定量表评估功能状况。
结果
MDD患者中4977bp缺失的发生率较高，且不受人口统计学或临床因素的影响。
结论
4977bp缺失可能是MDD的一个特质性标志物。
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