Böheim K, Spoendlin H
Acta Otolaryngol. 1985 Jul-Aug;100(1-2):134-9. doi: 10.3109/00016488509108598.
Results of a combined therapy, consisting of preoperative chemotherapy, radical resection and postoperative irradiation, of 51 locally advanced, previously untreated, resectable squamous cancers of the head and neck are reported. The overall response rate to chemotherapy was 58.5% (with 33% complete remissions) and higher in carcinomas of the oral cavity and hypopharynx than of the supraglottis and oropharynx. Three year survival was 53% for the entire group, 75% for hypopharyngeal, 58% for oral, 50% for supraglottic and 32% for oropharyngeal lesions, in responders to chemotherapy statistically significant higher than in non responders and only 18% in the fifteen patients who developed recurrences.
报告了对51例局部晚期、未经治疗、可切除的头颈部鳞状癌采用术前化疗、根治性切除和术后放疗的联合治疗结果。化疗的总体缓解率为58.5%（完全缓解率为33%），口腔和下咽癌的缓解率高于声门上区和口咽癌。整个组的三年生存率为53%，下咽癌为75%，口腔癌为58%，声门上区癌为50%，口咽癌为32%；化疗有反应者的生存率在统计学上显著高于无反应者，在出现复发的15例患者中生存率仅为18%。
