Nikaido Yasutaka, Urakami Hideyuki, Ishida Naoya, Okada Yohei, Kawami Yuki, Inui Takaki, Kameda Masahiro, Kajimoto Yoshinaga, Saura Ryuichi
Clinical Department of Rehabilitation, Osaka Medical and Pharmaceutical University Hospital, Osaka, Japan.
Graduate School of Health Sciences, Kio University, Nara, Japan.
Mov Disord Clin Pract. 2025 Apr 18. doi: 10.1002/mdc3.70084.
Falls along with gait-balance disturbances are important symptoms of idiopathic normal pressure hydrocephalus (iNPH).
This study aimed to validate the Functional Gait Assessment (FGA) item-difficulty hierarchy, determine its optimal fall cutoff value, and identify key items for assessing fall risk in iNPH.
One hundred eighty-eight iNPH patients underwent pre-intervention assessments using the FGA, timed up-and-go (TUG), 10-Meter Gait Speed (10MGS) tests, and their falls history in the past 6 months. Rasch analysis confirmed the validity of the FGA item-difficulty hierarchy and established the relationship between total scores and logit estimates. Logistic regression identified the optimal FGA cutoff value and key fall-related items.
The FGA's item-difficulty hierarchy was confirmed to range from item 5 ("gait and pivot turn") at -2.58 logits (easiest) to item 7 ("gait with narrow base of support") at 5.35 logits (most difficult). Total scores corresponded to logits from -10.39 (score 0) to 11.64 (score 30). The fall rate was 63.3%. The optimal FGA cutoff value was ≤15 points (area under curve [AUC]: 0.901, P < 0.001), outperforming TUG (AUC: 0.712) and 10MGS (AUC: 0.742). Key fall-related items (R: 0.545, P < 0.001) were item 2 ("change in gait speed"), item 7 ("gait with narrow base of support"), item 1 ("gait on level surface"), item 10 ("stair steps"), and item 5 ("gait and pivot turn").
Our findings may facilitate early diagnosis and timely interventions, including tailored rehabilitation and fall prevention strategies, by leveraging the item difficulty and characteristics of the FGA for iNPH patients.
跌倒以及步态平衡障碍是特发性正常压力脑积水(iNPH)的重要症状。
本研究旨在验证功能性步态评估(FGA)项目难度层次结构,确定其最佳跌倒临界值,并识别评估iNPH患者跌倒风险的关键项目。
188例iNPH患者在干预前使用FGA、计时起立行走测试(TUG)、10米步态速度测试(10MGS)进行评估,并记录其过去6个月的跌倒史。Rasch分析证实了FGA项目难度层次结构的有效性,并建立了总分与对数估计值之间的关系。逻辑回归确定了最佳FGA临界值和与跌倒相关的关键项目。
FGA的项目难度层次结构被确认为从-2.58对数单位的项目5(“步态和转身”,最容易)到5.35对数单位的项目7(“窄支撑面步态”,最难)。总分对应于从-10.39(得分0)到11.64(得分30)的对数单位。跌倒发生率为63.3%。最佳FGA临界值为≤15分(曲线下面积[AUC]:0.901,P<0.001),优于TUG(AUC:0.712)和10MGS(AUC:0.742)。与跌倒相关的关键项目(R:0.545,P<0.001)为项目2(“步态速度变化”)、项目7(“窄支撑面步态”)、项目1(“平地步态”)、项目10(“楼梯台阶”)和项目5(“步态和转身”)。
我们的研究结果可能有助于通过利用FGA对iNPH患者的项目难度和特征进行早期诊断和及时干预,包括量身定制的康复和预防跌倒策略。