隐匿于众目睽睽之下：斑马鱼中发现的一个新淋巴器官。
Hiding in plain sight: A new lymphoid organ discovered in zebrafish.
作者信息
Bakr Mohamed N, Langenau David M
机构信息
Molecular Pathology Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Krantz Family Center for Cancer Research, Massachusetts General Hospital , Charlestown, MA, USA.
出版信息
J Exp Med. 2025 Jun 2;222(6). doi: 10.1084/jem.20250321. Epub 2025 Apr 18.
A small, unassuming, fleshy lobe at the base of the pectoral fin of fish has long been overlooked by scientists. In this issue of JEM, Castranova et al. (https://doi.org/10.1084/jem.20241435) describe this structure as a new secondary lymphoid organ. Translucent and externally located, the axillary lymphoid organ (ALO) shares striking structural similarities with mammalian secondary lymphoid organs. Due to its position and optical accessibility, the zebrafish ALO permitted noninvasive, high-resolution imaging of immune cell dynamics in live animals. These studies revealed likely interactions between T, B, and macrophage cells, arguing that the ALO may function in adaptive immune cell activation and provide a nexus for immune cell trafficking and communication.
鱼类胸鳍基部一个小而不起眼的肉质叶长期以来一直被科学家忽视。在本期《细胞与分子医学杂志》中，卡斯特拉诺瓦等人（https://doi.org/10.1084/jem.20241435）将这种结构描述为一种新的二级淋巴器官。腋窝淋巴器官（ALO）半透明且位于体表，与哺乳动物二级淋巴器官有着惊人的结构相似性。由于其位置和光学可达性，斑马鱼的ALO允许对活体动物的免疫细胞动态进行无创、高分辨率成像。这些研究揭示了T细胞、B细胞和巨噬细胞之间可能的相互作用，表明ALO可能在适应性免疫细胞激活中发挥作用，并为免疫细胞运输和通讯提供一个枢纽。
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