Yamashita H, Nakayama I, Noguchi S, Murakami N, Yokoyama S, Mochizuki Y, Moriuchi A, Noguchi A
Acta Pathol Jpn. 1985 Mar;35(2):377-83. doi: 10.1111/j.1440-1827.1985.tb00582.x.
The relationship between the size of carcinomas and their histological characteristics such as encapsulation and sclerosis was studied using 157 cases of thyroid minute carcinomas with diameters less than 10 mm. When the diameter of the tumor was less than 1 mm, encapsulated carcinomas were not found, but they were presented in a group with a larger diameter. Sclerosing carcinomas were more frequently distributed in the group with a diameter less than 5 mm. With increasing tumor size, the carcinomas were reduced markedly in number and only two cases of sclerosing carcinoma were observed with a diameter more than 8 mm. It was concluded that thyroid minute carcinomas arise as nonencapsulated carcinoma, either sclerosing or non-sclerosing, followed by encapsulation at a later time and that some of the non-sclerosing carcinomas become apparent clinically, whereas most of the sclerosing carcinomas remain clinically silent throughout the entire life of the host.
利用157例直径小于10mm的甲状腺微小癌，研究了癌肿大小与其组织学特征（如包膜和硬化）之间的关系。当肿瘤直径小于1mm时，未发现有包膜的癌，但在直径较大的一组中出现。硬化性癌在直径小于5mm的组中分布更为频繁。随着肿瘤大小的增加，癌肿数量明显减少，直径超过8mm的仅观察到2例硬化性癌。得出的结论是，甲状腺微小癌最初表现为无包膜的癌，可为硬化性或非硬化性，随后在后期出现包膜，并且一些非硬化性癌在临床上变得明显，而大多数硬化性癌在宿主的整个生命过程中在临床上保持无症状。
