Ayala Diana I, Evans Nick P, Wilson Dan, Mouw Mark, Karnezos T Peter
Purina Animal Nutrition Center, Land O' Lakes, Gray Summit, MO 63039,
Adisseo USA Inc., Alpharetta, GA 30022.
Avian Dis. 2025 Apr;68(S1):521-524. doi: 10.1637/aviandiseases-D-24-00061.
Erysipelas is a zoonotic disease, causing acute infections in swine, poultry, and a wide variety of animals, including humans. In layers, erysipelas is considered an emerging disease characterized by hepatomegaly, splenomegaly, septicemia, and acute death. It affects flocks between 43 and 73 wk old and can result in 50% overall mortality. Layer hens possibly affected by an erysipelas outbreak were sampled in this study. Organs at necropsy showed the typical erysipelas lesions; the presence of was confirmed by selective plating and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The antimicrobial effect of a set of 20 proprietary direct-fed microbials (DFM), individual strains and in combinations, was analyzed against confirmed isolates, by agar-well diffusion assay. Nine of the strains screened in this study were found effective at inhibiting the growth of all four isolates from erysipelas cases. The findings of this study highlight the potential of using the DFMs to evaluate their efficacy as biocontrol alternatives to reduce the growth in poultry production.
丹毒是一种人畜共患病，可在猪、家禽和包括人类在内的多种动物中引发急性感染。在蛋鸡中，丹毒被视为一种以肝肿大、脾肿大、败血症和急性死亡为特征的新出现疾病。它影响43至73周龄的鸡群，可导致总体死亡率达50%。本研究对可能受丹毒疫情影响的蛋鸡进行了采样。尸检时的器官显示出典型的丹毒病变；通过选择性平板接种和基质辅助激光解吸电离飞行时间质谱法确认了[病原体名称]的存在。通过琼脂孔扩散试验，分析了一组20种专有的直接投喂微生物（DFM）、单个菌株及其组合对已确认的[病原体名称]分离株的抗菌效果。在本研究中筛选的[病原体名称]菌株中有9种被发现可有效抑制来自丹毒病例的所有4种[病原体名称]分离株的生长。本研究结果突出了使用这些DFM评估其作为生物防治替代品以减少家禽生产中[病原体名称]生长的功效的潜力。
