Park Soyoung, Ahn Yeon-Soon, Lim Jungyun, Yu Sol, Kim Younghee, Lee Jongin
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
Department of Medicine and Institute of Genomic Cohort, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, Republic of Korea.
Cancer Epidemiol. 2025 Aug;97:102822. doi: 10.1016/j.canep.2025.102822. Epub 2025 Apr 18.
The outbreak of lung disease among humidifier disinfectants (HDs) users lead to the identification of humidifier disinfectants-associated lung injury (HDLI) cases. Subsequent research highlighted the respiratory health risks associated HDs but the connection to lung cancer remained uncertain. To assess the risk of lung cancer development among individuals exposed to HDs and to investigate the characteristics of HDs exposure influencing the occurrence of lung cancer.
A cohort study was conducted using the national database, encompassing 7343 claimants exposed to HDs. The study focused on 195 confirmed lung cancer cases, employing the standardized incidence ratio (SIR) for comparisons with the general population, and the odds ratio (OR) using propensity score matching for internal comparisons.
The study found a significantly higher incidence of lung cancer among individuals exposed to HDs compared to the general Korean population, with elevated SIRs observed in both men and women (SIR = 3.43, 95 % CI = 2.81-4.13 for men; SIR = 11.19, 95 % CI = 8.95-13.82 for women). In the propensity score-matched case-control design, a longer duration of HDs use was associated with an increased risk of lung cancer (OR = 2.48, 95 % CI = 1.35-4.56 for using HDs for more than 49 months and OR = 1.02, 95 % CI = 1.01 - 1.03 for every one month).
The findings suggest a potential association between HDs exposure and an increased risk of lung cancer.
加湿器消毒剂（HDs）使用者中肺部疾病的爆发导致了加湿器消毒剂相关肺损伤（HDLI）病例的识别。随后的研究强调了与HDs相关的呼吸健康风险，但与肺癌的联系仍不确定。评估接触HDs个体患肺癌的风险，并调查影响肺癌发生的HDs接触特征。
使用国家数据库进行队列研究，纳入7343名接触HDs的索赔者。该研究聚焦于195例确诊肺癌病例，采用标准化发病比（SIR）与一般人群进行比较，并使用倾向得分匹配的优势比（OR）进行内部比较。
该研究发现，与韩国普通人群相比，接触HDs的个体肺癌发病率显著更高，男性和女性的SIR均升高（男性SIR = 3.43，95%CI = 2.81 - 4.13；女性SIR = 11.19，95%CI = 8.95 - 13.82）。在倾向得分匹配的病例对照设计中，使用HDs的时间越长，患肺癌的风险越高（使用HDs超过49个月的OR = 2.48，95%CI = 1.35 - 4.56；每使用一个月的OR = 1.02，95%CI = 1.01 - 1.03）。
研究结果表明接触HDs与肺癌风险增加之间可能存在关联。
